V.B1誘導体,特にTTEDの神経因性膀胱に対する効果に関する生化学的一考察

Abstract

TTFD, thiamin tetrahydro-furfuryl disulfide, on e of the long-acting active vitamin 131, shows a quite characteristic biological action which is called as "Alinamin Effect" This "Alinamin Effect" , which may not be developed by thiamin itself, has widely spreaded sites of its action not only pharmacological but also biochemical. Here, some analysis were made with biochemical viewpoint on the effect of TTFD on neurogenic bladder. It was found that TTFD has some controlling action on the dehydrogen a se systems corresponding the TCA-cycle, and it may develops well accomodated activities of tissue metabolism. Therefore the effect of TTFD on the mitochondrial respiration, concerning the oxidative phosphorylation as well as the electron transportation, was observed. Since the increase of mitochondrial respiration after TTFD supplem e ntation which might not be found after thiamin, could not be prevented by the foregoing addition of pCMB, the sulfhydryl radical of TTFD would not be regarded as an important reaction center for mitochondrial respiration as well as for hydrogen transportation in dehydrogenase reaction. Physico-chemically, TTFD would play a roll of proton acceptor in its molecular construction, while it would become as a high energy phosphate acceptor such as ADP in oxidative phosphorylation, and affect the mitochondrial respiration as well as the tissue metabolism. However, these assumptions have no experimental back-ground yet. After all, TTFD would change some physical properties of neurogenic vesical wall rather normal through its action on the tissue metabolism, and make the function well cooperated.