尿路感染症における大腸菌の線毛の役割について

Abstract

1)腎盂腎炎患者由来株では膀胱炎患者由来株よりもP線毛保有率が高かった.2) P線毛保有菌の大部分は1型線毛も有していた.3) P線毛保有菌は1型線毛保有菌よりも尿路上皮細胞に親和性が高かった.4)いずれの型の線毛保有菌も腎盂, 尿管, 膀胱上皮細胞ではその親和性に差はみられなかった

The incidence of P-fimbriated E. coli from patients with pyelonephritis, cystitis and asymptomatic bacteriuria was 78.6%, 31.9% and 22.2%, respectively. Almost all of the P-fimbriated E. coli have also type-1 fimbriae. In the in vitro test, P-fimbriated E. coli attached to the uroepithelial cells in higher number than the type 1 fimbriated E. coli. The results of the adhesion inhibition test suggested that simultaneous presence of P-and type 1 fimbriae is the most significant virulence factor in urinary tract infections.