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http://hdl.handle.net/2433/145219
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| Title: | Alpha-fetoprotein-producing pancreatic cancer cells possess cancer stem cell characteristics. |
| Authors: | Sasaki, Naoya
Ishii, Takamichi
Kamimura, Ryo
Kajiwara, Masatoshi
Machimoto, Takafumi
Nakatsuji, Norio
Suemori, Hirofumi
Ikai, Iwao
Yasuchika, Kentaro
Uemoto, Shinji |
| Author's alias: | 佐々木, 直也
石井, 隆道 |
| Keywords: | Cancer stem cell
Pancreatic cancer
Alpha-fetoprotein (AFP)
ATP-binding cassette
Sub-family A (ABC1)
Member 12 (ABCA12) |
| Issue Date: | 28-Sep-2011 |
| Publisher: | Elsevier Ireland Ltd. |
| Journal title: | Cancer letters |
| Volume: | 308 |
| Issue: | 2 |
| Start page: | 152 |
| End page: | 161 |
| DOI: | 10.1016/j.canlet.2011.04.023 |
| Abstract: | We aimed to demonstrate the existence of cancer stem cells in human pancreatic cancer, and to clarify that they are alpha-fetoprotein (AFP) producing cells. Six cell lines derived from human pancreatic cancers were examined, and AsPC-1 and PANC-1 were noted to express AFP. Single cell culture assays and xenotransplantation revealed that the AFP-producing cells had the capacity for self-renewal and differentiation, and that these cells were tumorigenic. Furthermore, they were resistant to anti-cancer agents. The ABCA12 transporter was expressed in the AFP-producing cells at a level more than twice as high as that in the non-AFP-producing cells. The AFP-producing cells were shown to be putative pancreatic cancer stem cells. Furthermore, the expression of ABCA12 appears to be associated with drug resistance. |
| Rights: | © 2011 Elsevier Ireland Ltd. |
| URI: | http://hdl.handle.net/2433/145219 |
| PubMed ID: | 21616586 |
| Appears in Collections: | Journal Articles |
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