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| Title: | Aggregate formation and radiolytic degradation of amphiphilic DNA block copolymer possessing disulfide bond. |
| Authors: | Tanabe, Kazuhito
Asada, Takumi
Nishimoto, Sei-Ichi |
| Author's alias: | 田邉, 一仁 |
| Keywords: | DNA block copolymer
X-irradiation
Hypoxic Conditions
Drugcarrier
DNA aggregates |
| Issue Date: | 1-Dec-2012 |
| Publisher: | Elsevier Ltd. |
| Journal title: | Bioorganic & medicinal chemistry letters |
| Volume: | 22 |
| Issue: | 23 |
| Start page: | 7045 |
| End page: | 7047 |
| DOI: | 10.1016/j.bmcl.2012.09.090 |
| Abstract: | We have designed a novel aggregate of DNA block copolymer (DBC) that is sensitive to hypoxic X-irradiation. The DBC consists of tetrahydropyrane-protected 2-hydroxyethyl methacrylate as a hydrophobic unit and oligodeoxynucleotides as a hydrophilic unit, which are linked to a radiation-sensitive disulfide bond. The DBC self-assembled efficiently to form aggregates that encapsulated small molecules such as nile red and pyrene. Hypoxic X-irradiation could then induce reductive degradation of the DBC aggregates via an exchange reaction of the disulfide bond to release guest molecules. |
| Rights: | © 2012 Elsevier Ltd. |
| URI: | http://hdl.handle.net/2433/162899 |
| PubMed ID: | 23084897 |
| Appears in Collections: | Journal Articles |
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