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Title: Aggregate formation and radiolytic degradation of amphiphilic DNA block copolymer possessing disulfide bond.
Authors: Tanabe, Kazuhito
Asada, Takumi
Nishimoto, Sei-Ichi
Author's alias: 田邉, 一仁
Keywords: DNA block copolymer
X-irradiation
Hypoxic Conditions
Drugcarrier
DNA aggregates
Issue Date: 1-Dec-2012
Publisher: Elsevier Ltd.
Journal title: Bioorganic & medicinal chemistry letters
Volume: 22
Issue: 23
Start page: 7045
End page: 7047
DOI: 10.1016/j.bmcl.2012.09.090
Abstract: We have designed a novel aggregate of DNA block copolymer (DBC) that is sensitive to hypoxic X-irradiation. The DBC consists of tetrahydropyrane-protected 2-hydroxyethyl methacrylate as a hydrophobic unit and oligodeoxynucleotides as a hydrophilic unit, which are linked to a radiation-sensitive disulfide bond. The DBC self-assembled efficiently to form aggregates that encapsulated small molecules such as nile red and pyrene. Hypoxic X-irradiation could then induce reductive degradation of the DBC aggregates via an exchange reaction of the disulfide bond to release guest molecules.
Rights: © 2012 Elsevier Ltd.
URI: http://hdl.handle.net/2433/162899
PubMed ID: 23084897
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