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Title: Dclk1 distinguishes between tumor and normal stem cells in the intestine
Authors: Nakanishi, Yuki
Seno, Hiroshi
Fukuoka, Ayumi
Ueo, Taro
Yamaga, Yuichi
Maruno, Takahisa
Nakanishi, Naoko
Kanda, Keitaro
Komekado, Hideyuki
Kawada, Mayumi
Isomura, Akihiro researcher_resolver
Kawada, Kenji kyouindb researcher_resolver
Sakai, Yoshiharu kyouindb researcher_resolver
Yanagita, Motoko
Kageyama, Ryoichiro kyouindb researcher_resolver
Kawaguchi, Yoshiya kyouindb researcher_resolver
Taketo, Makoto M kyouindb researcher_resolver
Yonehara, Shin kyouindb researcher_resolver
Chiba, Tsutomu
Author's alias: 妹尾, 浩
Keywords: tumor initiating cell
cancer stem cell
lineage tracing
colon cancer
Issue Date: 2-Dec-2012
Publisher: Nature Publishing Group
Journal title: Nature Genetics
Abstract: There is great interest in tumor stem cells (TSCs) as potential therapeutic targets; however, cancer therapies targeting TSCs are limited. A drawback is that TSC markers are often shared by normal stem cells (NSCs)1–4; thus, therapies that target these markers may cause severe injury to normal tissues. To identify a potential TSC-specific marker, we focused on doublecortin-like kinase 1 (Dclk1). Dclk1 was reported as a candidate NSC marker in the gut5, 6, but recent reports have implicated it as a marker of differentiated cells (for example, Tuft cells)7, 8. Using lineage-tracing experiments, we show here that Dclk1 does not mark NSCs in the intestine but instead marks TSCs that continuously produce tumor progeny in the polyps of ApcMin/+ mice. Specific ablation of Dclk1-positive TSCs resulted in a marked regression of polyps without apparent damage to the normal intestine. Our data suggest the potential for developing a therapy for colorectal cancer based on targeting Dclk1-positive TSCs.
Description: 癌幹細胞を特定するマーカー同定に成功 : 新世代の癌治療法開発に期待.京都大学プレスリリース.2012-12-03.
Rights: © 2012 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.
この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。This is not the published version. Please cite only the published version.
URI: http://hdl.handle.net/2433/163077
DOI(Published Version): 10.1038/ng.2481
Related Link: http://www.kyoto-u.ac.jp/ja/news_data/h/h1/news6/2012/121203_1.htm
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