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Title: Current concept of reverse cholesterol transport and novel strategy for atheroprotection.
Authors: Ono, Koh
Author's alias: 尾野, 亘
Keywords: High-density lipoprotein cholesterol
Low-density lipoprotein cholesterol
Statin
Coronary heart disease
Atherosclerosis
MicroRNA
Issue Date: Nov-2012
Publisher: Elsevier Ireland Ltd.
Journal title: Journal of cardiology
Volume: 60
Issue: 5
Start page: 339
End page: 343
DOI: 10.1016/j.jjcc.2012.07.014
Abstract: Elevated levels of low-density lipoprotein cholesterol (LDL-C) increase the risk of coronary heart disease (CHD), but pharmacologic therapy to decrease LDL-C significantly reduces the risk of cardiovascular events. Despite the effectiveness of statin therapy, there remains significant residual cardiovascular risk. A low plasma concentration of high-density lipoprotein cholesterol (HDL-C) is associated with increased risk of CHD. Moreover, recent studies have shown that HDL-C levels during statin treatment remain an independent predictor of the risk of cardiovascular events. However, recent clinical trials aimed at reducing CHD risk by raising HDL-C levels have not shown satisfactory results and it is becoming evident that a functional HDL-C is a more desirable target than simply elevating its level. This review summarizes the function of HDL-C in reverse cholesterol transfer from peripheral tissue and discusses the latest HDL-targeting therapeutic strategies including the manipulation of microRNAs.
Rights: © 2012 Japanese College of Cardiology. Published by Elsevier Ireland Ltd.
URI: http://hdl.handle.net/2433/163080
PubMed ID: 23063661
Appears in Collections:Journal Articles


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