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タイトル: | An evolutionarily conserved protein CHORD regulates scaling of dendritic arbors with body size. |
著者: | Shimono, Kohei Fujishima, Kazuto Nomura, Takafumi Ohashi, Masayoshi Usui, Tadao https://orcid.org/0000-0002-0507-1495 (unconfirmed) Kengaku, Mineko https://orcid.org/0000-0002-1666-3648 (unconfirmed) Toyoda, Atsushi Uemura, Tadashi https://orcid.org/0000-0001-7204-3606 (unconfirmed) |
著者名の別形: | 下野, 耕平 上村, 匡 |
キーワード: | Developmental biology Cell biology |
発行日: | 19-Mar-2014 |
出版者: | Nature Publishing Group |
誌名: | Scientific reports |
巻: | 4 |
論文番号: | 4415 |
抄録: | Most organs scale proportionally with body size through regulation of individual cell size and/or cell number. Here we addressed how postmitotic and morphologically complex cells such as neurons scale with the body size by using the dendritic arbor of one Drosophila sensory neuron as an assay system. In small adults eclosed under a limited-nutrition condition, the wild-type neuron preserved the branching complexity of the arbor, but scaled down the entire arbor, making a "miniature". In contrast, mutant neurons for the Insulin/IGF signaling (IIS) or TORC1 pathway exhibited "undergrowth", which was characterized by decreases in both the branching complexity and the arbor size, despite a normal diet. These contrasting phenotypes hinted that a novel regulatory mechanism contributes to the dendritic scaling in wild-type neurons. Indeed, we isolated a mutation in the gene CHORD/morgana that uncoupled the neuron size and the body size: CHORD mutant neurons generated miniature dendritic arbors regardless of the body size. CHORD encodes an evolutionarily conserved co-chaperone of HSP90. Our results support the notion that dendritic growth and branching are controlled by partly separate mechanisms. The IIS/TORC1 pathways control both growth and branching to avert underdevelopment, whereas CHORD together with TORC2 realizes proportional scaling of the entire arbor. |
記述: | 体の大きさに合わせて神経細胞の大きさを制御するしくみを解明. 京都大学プレスリリース. 2014-03-17. |
著作権等: | This work is licensed under a Creative Commons Attribution-NonCommercial-ShareALike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/ |
URI: | http://hdl.handle.net/2433/185056 |
DOI(出版社版): | 10.1038/srep04415 |
PubMed ID: | 24643112 |
関連リンク: | https://www.kyoto-u.ac.jp/static/ja/news_data/h/h1/news6/2013_1/140317_1.htm |
出現コレクション: | 学術雑誌掲載論文等 |
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