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タイトル: | Perivascular leukocyte clusters are essential for efficient activation of effector T cells in the skin. |
著者: | Natsuaki, Yohei Egawa, Gyohei Nakamizo, Satoshi https://orcid.org/0000-0001-9332-0369 (unconfirmed) Ono, Sachiko Hanakawa, Sho Okada, Takaharu Kusuba, Nobuhiro Otsuka, Atsushi Kitoh, Akihiko Honda, Tetsuya Nakajima, Saeko https://orcid.org/0000-0003-0831-1447 (unconfirmed) Tsuchiya, Soken Sugimoto, Yukihiko Ishii, Ken J Tsutsui, Hiroko Yagita, Hideo Iwakura, Yoichiro Kubo, Masato Ng, Lai Guan Hashimoto, Takashi Fuentes, Judilyn Guttman-Yassky, Emma Miyachi, Yoshiki Kabashima, Kenji https://orcid.org/0000-0002-0773-0554 (unconfirmed) |
著者名の別形: | 夏秋, 洋平 江川, 形平 椛島, 健治 |
発行日: | 21-Sep-2014 |
出版者: | Nature Publishing Group |
誌名: | Nature immunology |
巻: | 15 |
開始ページ: | 1064 |
終了ページ: | 1069 |
抄録: | It remains largely unclear how antigen-presenting cells (APCs) encounter effector or memory T cells efficiently in the periphery. Here we used a mouse contact hypersensitivity (CHS) model to show that upon epicutaneous antigen challenge, dendritic cells (DCs) formed clusters with effector T cells in dermal perivascular areas to promote in situ proliferation and activation of skin T cells in a manner dependent on antigen and the integrin LFA-1. We found that DCs accumulated in perivascular areas and that DC clustering was abrogated by depletion of macrophages. Treatment with interleukin 1α (IL-1α) induced production of the chemokine CXCL2 by dermal macrophages, and DC clustering was suppressed by blockade of either the receptor for IL-1 (IL-1R) or the receptor for CXCL2 (CXCR2). Our findings suggest that the dermal leukocyte cluster is an essential structure for elicitating acquired cutaneous immunity. |
記述: | かぶれの発症における血管周囲の免疫細胞の集積の重要性の解明. 京都大学プレスリリース. 2014-09-24. |
著作権等: | © 2014 Nature America, Inc. 許諾条件により本文は2015-03-22に公開. This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 |
URI: | http://hdl.handle.net/2433/189891 |
DOI(出版社版): | 10.1038/ni.2992 |
PubMed ID: | 25240383 |
関連リンク: | https://www.kyoto-u.ac.jp/ja/research-news/2014-09-24 |
出現コレクション: | 学術雑誌掲載論文等 |
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