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j.jpsychires.2014.09.001.pdf | 1.8 MB | Adobe PDF | 見る/開く |
タイトル: | Fiber tract associated with autistic traits in healthy adults. |
著者: | Hirose, Kimito Miyata, Jun https://orcid.org/0000-0003-1803-1975 (unconfirmed) Sugihara, Genichi Kubota, Manabu Sasamoto, Akihiko Aso, Toshihiko https://orcid.org/0000-0003-4814-089X (unconfirmed) Fukuyama, Hidenao Murai, Toshiya Takahashi, Hidehiko |
著者名の別形: | 廣瀬, 公人 高橋, 英彦 |
キーワード: | Autism Tract-based spatial statistics Tractography Posterior superior temporal sulcus Inferior fronto-occipital fasciculus |
発行日: | Dec-2014 |
出版者: | Elsevier Ltd. |
誌名: | Journal of psychiatric research |
巻: | 59 |
開始ページ: | 117 |
終了ページ: | 124 |
抄録: | Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder with impairment of social communication and restricted and repetitive behaviors. Reduced fractional anisotropy (FA), a measure of white matter integrity, in the posterior superior temporal sulcus (pSTS) is related to ASD. However, there are several major fibers in pSTS, and it is unknown which of them is associated with ASD. We investigated FA in correlation with autistic traits assessed by autism spectrum quotient (AQ) in 91 healthy adults using tract-based spatial statistics (TBSS). Then, of the fibers in pSTS, we identified the one in which FA was linked to the AQ score using tractography. TBSS revealed that AQ was correlated with FA of white matter in several regions such as the frontal lobe, parietal lobe, occipital lobe and temporal lobe including pSTS. With further analysis using tractography, we confirmed that FA alteration in pSTS was located on the inferior fronto-occipital fasciculus (IFOF). IFOF has a critical role in processing socio-emotional information. Our findings suggest that of the fibers in pSTS, IFOF is a key fiber that links to autistic traits in healthy adults. |
著作権等: | © 2014 Elsevier Ltd. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 This is not the published version. Please cite only the published version. |
URI: | http://hdl.handle.net/2433/191261 |
DOI(出版社版): | 10.1016/j.jpsychires.2014.09.001 |
PubMed ID: | 25266474 |
出現コレクション: | 学術雑誌掲載論文等 |
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