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ファイル | 記述 | サイズ | フォーマット | |
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60_543.pdf | 1.17 MB | Adobe PDF | 見る/開く |
タイトル: | 京都大学病院での前立腺全摘術における神経温存適応基準構築に関する検討 |
その他のタイトル: | Development of a Preoperative Criterion to Select Candidates for Nerve-Sparing Radical Prostatectomy at Kyoto University Hospital |
著者: | 水野, 桂 井上, 貴博 宮崎, 有 牧野, 雄樹 寺田, 直樹 小林, 恭 山﨑, 俊成 松井, 喜之 神波, 大己 吉村, 耕治 三上, 芳喜 小川, 修 |
著者名の別形: | Mizuno, Kei Inoue, Takahiro Miyazaki, Yu Makino, Yuki Terada, Naoki Kobayashi, Takashi Yamasaki, Toshinari Matsui, Yoshiyuki Kamba, Tomomi Yoshimura, Koji Mikami, Yoshiki Ogawa, Osamu |
キーワード: | Radical Prostatectomy Nerve-sparing |
発行日: | Nov-2014 |
出版者: | 泌尿器科紀要刊行会 |
誌名: | 泌尿器科紀要 |
巻: | 60 |
号: | 11 |
開始ページ: | 543 |
終了ページ: | 547 |
抄録: | Neurovascular bundle (NVB) preservation is a mandatory procedure to maintain erectile function of localized prostate cancer patients after radical prostatectomy (RP). However, in terms of cancer control, indications to select appropriate patients for nerve-sparing RP are still controversial. In this study, we examined the pathological findings of RP specimens to develop a preoperative criterion for NVB preservation during RP. The study included 76 patients who underwent RP at our institution from 2006 to 2008, and we retrospectively analyzed RP specimens pathologically. The distance between NVB and foci of prostate cancer was measured in 135 prostate sides, and preoperative factors which predict the distance of ≤2 mm was evaluated. Univariate analysis showed that side-specific positive biopsy core rate ≥33.3%, sidespecific maximum tumor length in biopsy core ≥5 mm and side-specific tumor involvement rate in biopsy core ≥50% was associated with the risk of the distance of ≤2 mm. Multivariate analysis revealed that sidespecific positive biopsy core rate ≥33.3% was the only significant predictor of the ipsilateral NVB-tumor distance ≤2 mm (p=0.0055, odds ratio 3.49). Based on this study, a nerve-sparing criterion of <33.3% side-specific percent positive biopsy core was developed at our institution. Prospective data on patients who were applied this criterion are needed to evaluate its clinical safety and feasibility. |
著作権等: | 許諾条件により本文は2015/12/01に公開 |
URI: | http://hdl.handle.net/2433/192328 |
PubMed ID: | 25511940 |
出現コレクション: | Vol. 60 No. 11 |
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