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タイトル: | Exosomes as nanocarriers for systemic delivery of the Helicobacter pylori virulence factor CagA |
著者: | Shimoda, Asako Ueda, Koji Nishiumi, Shin Murata-Kamiya, Naoko Mukai, Sada-atsu Sawada, Shin-ichi Azuma, Takeshi Hatakeyama, Masanori Akiyoshi, Kazunari |
著者名の別形: | 植田, 幸嗣 澤田, 晋一 東, 健 畠山, 昌則 秋吉, 一成 |
発行日: | 7-Jan-2016 |
出版者: | Nature Publishing Group |
誌名: | Scientific Reports |
巻: | 6 |
論文番号: | 18346 |
抄録: | CagA, encoded by cytotoxin-associated gene A (cagA), is a major virulence factor of Helicobacter pylori, a gastric pathogen involved in the development of upper gastrointestinal diseases. Infection with cagA-positive H. pylori may also be associated with diseases outside the stomach, although the mechanisms through which H. pylori infection promotes extragastric diseases remain unknown. Here, we report that CagA is present in serum-derived extracellular vesicles, known as exosomes, in patients infected with cagA-positive H. pylori (n = 4). We also found that gastric epithelial cells inducibly expressing CagA secrete exosomes containing CagA. Addition of purified CagA-containing exosomes to gastric epithelial cells induced an elongated cell shape, indicating that the exosomes deliver functional CagA into cells. These findings indicated that exosomes secreted from CagA-expressing gastric epithelial cells may enter into circulation, delivering CagA to distant organs and tissues. Thus, CagA-containing exosomes may be involved in the development of extragastric disorders associated with cagA-positive H. pylori infection. |
記述: | ピロリ菌由来病原タンパク質CagAを全身に運ぶ小胞を発見 -ピロリ菌感染に よる非消化器疾患の発症メカニズムの解明へ-. 京都大学プレスリリース. 2016-01-08. |
著作権等: | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
URI: | http://hdl.handle.net/2433/203011 |
DOI(出版社版): | 10.1038/srep18346 |
PubMed ID: | 26739388 |
関連リンク: | https://www.kyoto-u.ac.jp/ja/research-news/2016-01-08-0 |
出現コレクション: | 学術雑誌掲載論文等 |
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