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j.stemcr.2016.01.005.pdf | 3.68 MB | Adobe PDF | 見る/開く |
タイトル: | Cellular Adjuvant Properties, Direct Cytotoxicity of Re-differentiated Vα24 Invariant NKT-like Cells from Human Induced Pluripotent Stem Cells. |
著者: | Kitayama, Shuichi Zhang, Rong Liu, Tian-Yi Ueda, Norihiro Iriguchi, Shoichi Yasui, Yutaka Kawai, Yohei Tatsumi, Minako Hirai, Norihito Mizoro, Yasutaka Iwama, Tatsuaki Watanabe, Akira Nakanishi, Mahito Kuzushima, Kiyotaka Uemura, Yasushi Kaneko, Shin ![]() ![]() |
著者名の別形: | 喜多山, 秀一 植村, 靖史 金子, 新 |
発行日: | 9-Feb-2016 |
出版者: | Elsevier Inc. |
誌名: | Stem cell reports |
巻: | 6 |
号: | 2 |
開始ページ: | 213 |
終了ページ: | 227 |
抄録: | Vα24 invariant natural killer T (iNKT) cells are a subset of T lymphocytes implicated in the regulation of broad immune responses. They recognize lipid antigens presented by CD1d on antigen-presenting cells and induce both innate and adaptive immune responses, which enhance effective immunity against cancer. Conversely, reduced iNKT cell numbers and function have been observed in many patients with cancer. To recover these numbers, we reprogrammed human iNKT cells to pluripotency and then re-differentiated them into regenerated iNKT cells in vitro through an IL-7/IL-15-based optimized cytokine combination. The re-differentiated iNKT cells showed proliferation and IFN-γ production in response to α-galactosylceramide, induced dendritic cell maturation and downstream activation of both cytotoxic T lymphocytes and NK cells, and exhibited NKG2D- and DNAM-1-mediated NK cell-like cytotoxicity against cancer cell lines. The immunological features of re-differentiated iNKT cells and their unlimited availability from induced pluripotent stem cells offer a potentially effective immunotherapy against cancer. |
記述: | ヒトiPS細胞から、免疫機能を活性化させる細胞の作製に成功. 京都大学プレスリリース. 2016-03-24. |
著作権等: | © 2016 The Authors. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
URI: | http://hdl.handle.net/2433/210023 |
DOI(出版社版): | 10.1016/j.stemcr.2016.01.005 |
PubMed ID: | 26862702 |
関連リンク: | https://www.kyoto-u.ac.jp/ja/research-news/2016-03-24-0 |
出現コレクション: | 学術雑誌掲載論文等 |
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