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| ファイル | 記述 | サイズ | フォーマット | |
|---|---|---|---|---|
| 962941.pdf | 2.51 MB | Adobe PDF | 見る/開く |
| タイトル: | Amylose-Based Cationic Star Polymers for siRNA Delivery |
| 著者: | Nishimura, Tomoki Umezaki, Kaori Mukai, Sada Atsu Sawada, Shin Ichi Akiyoshi, Kazunari   |
| 著者名の別形: | 向井, 貞篤 澤田, 晋一 秋吉, 一成 |
| 発行日: | 2015 |
| 出版者: | Hindawi Publishing Corporation |
| 誌名: | BioMed Research International |
| 巻: | 2015 |
| 論文番号: | 962941 |
| 抄録: | A new siRNA delivery system using a cationic glyco-star polymer is described. Spermine-modified 8-arm amylose star polymer (with a degree of polymerization of approximately 60 per arm) was synthesized by chemoenzymatic methods. The cationic star polymer effectively bound to siRNA and formed spherical complexes with an average hydrodynamic diameter of 230 nm. The cationic 8-arm star polymer complexes showed superior cellular uptake characteristics and higher gene silencing effects than a cationic 1-arm polymer. These results suggest that amylose-based star polymers are a promising nanoplatform for glycobiomaterials. |
| 著作権等: | © 2015 Tomoki Nishimura et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| URI: | http://hdl.handle.net/2433/210261 |
| DOI(出版社版): | 10.1155/2015/962941 |
| PubMed ID: | 26539548 |
| 出現コレクション: | 学術雑誌掲載論文等 |
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