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j.eplepsyres.2015.12.003.pdf1.33 MBAdobe PDF見る/開く
タイトル: Network specific change in white matter integrity in mesial temporal lobe epilepsy
著者: Imamura, Hisaji
Matsumoto, Riki  KAKEN_id  orcid https://orcid.org/0000-0003-3985-9210 (unconfirmed)
Takaya, Shigetoshi
Nakagawa, Tomokazu
Shimotake, Akihiro  kyouindb  KAKEN_id
Kikuchi, Takayuki  kyouindb  KAKEN_id
Sawamoto, Nobukatsu  kyouindb  KAKEN_id
Kunieda, Takeharu
Mikuni, Nobuhiro
Miyamoto, Susumu
Fukuyama, Hidenao
Takahashi, Ryosuke  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0002-1407-9640 (unconfirmed)
Ikeda, Akio  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0002-0790-2598 (unconfirmed)
著者名の別形: 今村, 久司
松本, 理器
髙屋, 成利
中川, 朋一
下竹, 昭寛
菊池, 隆幸
澤本, 伸克
國枝, 武治
三國, 信啓
宮本, 享
福山, 秀直
髙橋, 良輔
池田, 昭夫
キーワード: FDG-PET
Diffusion tractography
Mesial temporal lobe epilepsy
Epileptic activity
Seizure propagation
発行日: 1-Feb-2016
出版者: Elsevier B.V.
誌名: Epilepsy Research
巻: 120
開始ページ: 65
終了ページ: 72
抄録: Objectives: To identify the specific change of white matter integrity that occurs in the brain network related to epileptic activity in patients with mesial temporal lobe epilepsy (MTLE). Methods: We recruited 18 patients with MTLE and 18 healthy subjects. In MTLE patients, the remote functional-deficit zone was delineated using fluorodeoxyglucose positron emission tomography as an extratemporal region showing glucose hypometabolism. Using diffusion magnetic resonance imaging tractography, we defined a seizure propagation tract (PT) as a white matter pathway that connects the focus with a remote functional deficit zone. We also used the corticospinal tract (CST) and inferior longitudinal fasciculus (ILF) as control tracts in the hemisphere ipsilateral to the focus. Fractional anisotropy (FA), mean diffusivity (MD), and volume of the tracts were compared among PT, CST, and ILF. Results: Tractographic analysis identified the uncinate fasciculus, arcuate fasciculus, and fornix as PTs. A decrease in FA was found in MTLE patients compared with healthy subjects in all tracts, but PTs showed a more significant decrease in FA than did the two control tracts. Although the change in MD was also found in MTLE patients compared with healthy controls, a tract-specific change was not observed. Although white-matter damage was observed in all candidate tracts examined, the integrity of white matter was most significantly decreased in PTs in MTLE. Conclusion: The change in white matter integrity occurs specifically in the pathways that connect the focus and remote functional deficit zones in patients with MTLE, i.e., the pathways that are assume to be associated with seizure propagation.
記述: 学位論文(出版社版): http://hdl.handle.net/2433/226747
著作権等: ©2015. This preprint version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
This is not the published version. Please cite only the published version.
この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
URI: http://hdl.handle.net/2433/210294
DOI(出版社版): 10.1016/j.eplepsyres.2015.12.003
PubMed ID: 26735187
関連リンク: http://hdl.handle.net/2433/226747
出現コレクション:学術雑誌掲載論文等

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