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タイトル: | Pharmacokinetics of chiral dendrimer-triamine-coordinated Gd-MRI contrast agents evaluated by in Vivo MRI and estimated by in Vitro QCM |
著者: | Miyake, Yuka Ishikawa, Syungo Kimura, Yu https://orcid.org/0000-0001-5318-9255 (unconfirmed) Son, Aoi Imai, Hirohiko Matsuda, Tetsuya Yamada, Hisatsugu Toshimitsu, Akio Kondo, Teruyuki |
著者名の別形: | 木村, 祐 今井, 宏彦 松田, 哲也 近藤, 輝幸 |
キーワード: | chiral dendrimer gadolinium contrast agent magnetic resonance imaging (MRI) quartz crystal microbalance (QCM) association constant (Ka) |
発行日: | 18-Dec-2015 |
出版者: | MDPI AG |
誌名: | Sensors |
巻: | 15 |
号: | 12 |
開始ページ: | 31973 |
終了ページ: | 31986 |
抄録: | Recently, we developed novel chiral dendrimer-triamine-coordinated Gd-MRI contrast agents (Gd-MRI CAs), which showed longitudinal relaxivity (r1) values about four times higher than that of clinically used Gd-DTPA (Magnevist®, Bayer). In our continuing study of pharmacokinetic differences derived from both the chirality and generation of Gd-MRI CAs, we found that the ability of chiral dendrimer Gd-MRI CAs to circulate within the body can be directly evaluated by in vitro MRI (7 T). In this study, the association constants (Ka) of chiral dendrimer Gd-MRI CAs to bovine serum albumin (BSA), measured and calculated with a quartz crystal microbalance (QCM) in vitro, were found to be an extremely easy means for evaluating the body-circulation ability of chiral dendrimer Gd-MRI CAs. The Ka values of S-isomeric dendrimer Gd-MRI CAs were generally greater than those of R-isomeric dendrimer Gd-MRI CAs, which is consistent with the results of our previous MRI study in vivo. |
著作権等: | © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
URI: | http://hdl.handle.net/2433/210694 |
DOI(出版社版): | 10.3390/s151229900 |
PubMed ID: | 26694418 |
出現コレクション: | 学術雑誌掲載論文等 |
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