ダウンロード数: 168

このアイテムのファイル:
ファイル 記述 サイズフォーマット 
bmjopen-2015-008356.pdf459.48 kBAdobe PDF見る/開く
タイトル: Multicentre, randomised, placebocontrolled trial of extract of Japanese herbal medicine Daikenchuto to prevent bowel dysfunction after adult liver transplantation (DKB 14 Study)
著者: Kaido, Toshimi  KAKEN_id
Shimamura, Tsuyoshi
Sugawara, Yasuhiko
Sadamori, Hiroshi
Shirabe, Ken
Yamamoto, Michio  KAKEN_id
Uemoto, Shinji  KAKEN_id
著者名の別形: 海道, 利実
上本, 伸二
発行日: 29-Sep-2015
出版者: BMJ Publishing Group
誌名: BMJ Open
巻: 5
論文番号: e008356
抄録: Introduction: This multicentre randomised controlled clinical trial will aim to determine the ability of an extract (TJ-100) of Daikenchuto (traditional Japanese herbal medicine; Kampo) to prevent bowel dysfunction in at least 110 patients after liver transplantation (LT). Methods and analysis: The following co-primary end points will be evaluated on postoperative day 7: total oral and enteral caloric intake, abdominal distension and abdominal pain. The secondary end points will comprise sequential changes of total oral and enteral caloric intake after LT, sequential changes in numeric rating scales for abdominal distension and pain, elapsed time to the first postoperative passage of stool, quality of life assessment using the Gastrointestinal Symptom Rating Scale score (Japanese version), postoperative liver function, liver regeneration rate, incidence of bacteraemia and bacterial strain, trough level of immunosuppressants, occurrence of acute cellular rejection, discharge or not within 2 months after LT, sequential changes of portal venous flow to the graft and ascites discharge. The two arms of the study will comprise 55 patients per arm. Ethics and dissemination: The study has been conducted according to the CONSORT statement. All participants signed a written consent form, and the study has been approved by the institutional review board of each participating institute and conducted in accordance with the Declaration of Helsinki of 1996. The findings will be disseminated through scientific and professional conferences, and in peer-reviewed journals.
著作権等: This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
URI: http://hdl.handle.net/2433/216062
DOI(出版社版): 10.1136/bmjopen-2015-008356
PubMed ID: 26419681
出現コレクション:学術雑誌掲載論文等

アイテムの詳細レコードを表示する

Export to RefWorks


出力フォーマット 


このリポジトリに保管されているアイテムはすべて著作権により保護されています。