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| タイトル: | Genome-wide association studies in East Asians identify new loci for waist-hip ratio and waist circumference |
| 著者: | Wen, Wanqing Kato, Norihiro Hwang, Joo Yeon Guo, Xingyi Tabara, Yasuharu  Li, Huaixing Dorajoo, Rajkumar Yang, Xiaobo Tsai, Fuu Jen Li, Shengxu Wu, Ying Wu, Tangchun Kim, Soriul Guo, Xiuqing Liang, Jun Shungin, Dmitry Adair, Linda S. Akiyama, Koichi Allison, Matthew Cai, Qiuyin Chang, Li Ching Chen, Chien Hsiun Chen, Yuan Tsong Cho, Yoon Shin Choi, Bo Youl Gao, Yutang Go, Min Jin Gu, Dongfeng Han, Bok Ghee He, Meian Hixson, James E. Hu, Yanling Huang, Tao Isono, Masato Jung, Keum Ji Kang, Daehee Kim, Young Jin Kita, Yoshikuni Lee, Juyoung Lee, Nanette R. Lee, Jeannette Wang, Yiqin Liu, Jian Jun Long, Jirong Moon, Sanghoon Nakamura, Yasuyuki Nakatochi, Masahiro Ohnaka, Keizo Rao, Dabeeru Shi, Jiajun Sull, Jae Woong Tan, Aihua Ueshima, Hirotsugu Wu, Chen Xiang, Yong Bing Yamamoto, Ken Yao, Jie Ye, Xingwang Yokota, Mitsuhiro Zhang, Xiaomin Zheng, Yan Qi, Lu Rotter, Jerome I. Jee, Sun Ha Lin, Dongxin Mohlke, Karen L. He, Jiang Mo, Zengnan Wu, Jer Yuarn Tai, E. Shyong Lin, Xu Miki, Tetsuro Kim, Bong Jo Takeuchi, Fumihiko Zheng, Wei Shu, Xiao Ou |
| 著者名の別形: | 田原, 康玄 |
| 発行日: | 20-Jan-2016 |
| 出版者: | Nature Publishing Group |
| 誌名: | Scientific Reports |
| 巻: | 6 |
| 論文番号: | 17958 |
| 抄録: | Sixty genetic loci associated with abdominal obesity, measured by waist circumference (WC) and waist-hip ratio (WHR), have been previously identified, primarily from studies conducted in European-ancestry populations. We conducted a meta-analysis of associations of abdominal obesity with approximately 2.5 million single nucleotide polymorphisms (SNPs) among 53, 052 (for WC) and 48, 312 (for WHR) individuals of Asian descent, and replicated 33 selected SNPs among 3, 762 to 17, 110 additional individuals. We identified four novel loci near the EFEMP1, ADAMTSL3, CNPY2, and GNAS genes that were associated with WC after adjustment for body mass index (BMI); two loci near the NID2 and HLA-DRB5 genes associated with WHR after adjustment for BMI, and three loci near the CEP120, TSC22D2, and SLC22A2 genes associated with WC without adjustment for BMI. Functional enrichment analyses revealed enrichment of corticotropin-releasing hormone signaling, GNRH signaling, and/or CDK5 signaling pathways for those newly-identified loci. Our study provides additional insight on genetic contribution to abdominal obesity. |
| 著作権等: | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| URI: | http://hdl.handle.net/2433/216138 |
| DOI(出版社版): | 10.1038/srep17958 |
| PubMed ID: | 26785701 |
| 出現コレクション: | 学術雑誌掲載論文等 |
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