ダウンロード数: 153
このアイテムのファイル:
ファイル | 記述 | サイズ | フォーマット | |
---|---|---|---|---|
journal.pone.0160317.pdf | 4.33 MB | Adobe PDF | 見る/開く |
タイトル: | In vivo choroidal vascular lesions in diabetes on swept-source optical coherence tomography |
著者: | Murakami, Tomoaki Uji, Akihito Suzuma, Kiyoshi Dodo, Yoko Yoshitake, Shin Ghashut, Rima Yoza, Rina Fujimoto, Masahiro Yoshimura, Nagahisa |
著者名の別形: | 村上, 智昭 宇治, 彰人 鈴間, 潔 百々, 蓉子 吉武, 信 吉村, 長久 |
発行日: | 1-Aug-2016 |
出版者: | Public Library of Science |
誌名: | PLOS ONE |
巻: | 11 |
号: | 8 |
論文番号: | e0160317 |
抄録: | Diabetes induces microvascular diseases including diabetic retinopathy and choroidopathy which reciprocally promote the pathogenesis, although optical coherence tomography images of diabetic choroidopathy remains to be documented. Here we evaluated the qualitative characteristics of choroidal vascular lesions in patients with diabetes and their association with diabetic retinopathy on swept-source optical coherence tomography (SS-OCT) images. We retrospectively reviewed 110 consecutive eyes of 110 patients with diabetes and 35 eyes of 35 healthy subjects for whom SS-OCT images (6x6-mm scans centered on the fovea) of sufficient quality were acquired. The curve of chorioretinal sections was flattened using Bruch's membrane as a reference surface, followed by generation of en-face images. We characterized choroidal vascular lesions and evaluated their association with the logarithm of the minimum angle of resolution visual acuity (logMAR VA), retinal and choroidal thicknesses, and diabetic retinopathy severity. En-face SS-OCT images showed unvisualized vessels in Sattler's layer in 33 eyes (30.0%). Focal narrowing was seen in choroidal vessels in Haller's layer in 56 eyes (50.9%). The choroidal vessels ended in the superficial or middle portion of Haller's layer, referred to as vascular stumps, in 20 eyes (18.2%). Diabetic eyes had these findings more frequently than nondiabetic eyes. The subfoveal choroid was thicker in eyes with focal vascular narrowing and vascular stumps than in eyes without such lesions. Vascular stumps in Haller's layer were significantly related to diabetic retinopathy severity, logMAR VA, and central retinal and choroidal thicknesses. These novel findings on SS-OCT images would promote the better understanding of complicated pathogenesis in diabetic retinopathy and choroidopathy. |
著作権等: | © 2016 Murakami et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
URI: | http://hdl.handle.net/2433/216400 |
DOI(出版社版): | 10.1371/journal.pone.0160317 |
PubMed ID: | 27479070 |
出現コレクション: | 学術雑誌掲載論文等 |
このリポジトリに保管されているアイテムはすべて著作権により保護されています。