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タイトル: | High maltose sensitivity of sweet taste receptors in the Japanese macaque (Macaca fuscata). |
著者: | Nishi, Emiko Tsutsui, Kei Imai, Hiroo |
著者名の別形: | 西, 栄美子 筒井, 圭 今井, 啓雄 |
発行日: | 16-Dec-2016 |
出版者: | Springer Nature |
誌名: | Scientific reports |
巻: | 6 |
論文番号: | 39352 |
抄録: | Taste sensitivity differs among animal species depending on feeding habitat. To humans, sucrose is one of the sweetest natural sugars, and this trait is expected to be similar in other primates. However, previous behavioral tests have shown that some primate species have equal preferences for maltose and sucrose. Because sweet tastes are recognized when compounds bind to the sweet taste receptor Tas1R2/Tas1R3, we evaluated the responses of human and Japanese macaque Tas1R2/Tas1R3 to various natural sugars using a heterologous expression system. Human Tas1R2/Tas1R3 showed high sensitivity to sucrose, as expected; however, Japanese macaque Tas1R2/Tas1R3 showed equally high sensitivity to maltose and sucrose. Furthermore, Japanese macaques showed equally high sensitivity to sucrose and maltose in a two-bottle behavioral experiment. These results indicate that Japanese macaques have high sensitivity to maltose, and this sensitivity is directly related to Tas1R2/Tas1R3 function. This is the first molecular biological evidence that for some primate species, sucrose is not the most preferable natural sugar, as it is for humans. |
記述: | ニホンザルの甘味受容体がすごい : ヒトが感じられない麦芽糖の甘みにも敏感. 京都大学プレスリリース. 2016-12-26. |
著作権等: | © The Author(s) 2016. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
URI: | http://hdl.handle.net/2433/217687 |
DOI(出版社版): | 10.1038/srep39352 |
PubMed ID: | 27982108 |
関連リンク: | https://www.kyoto-u.ac.jp/ja/research-news/2016-12-26-0 |
出現コレクション: | 学術雑誌掲載論文等 |
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