ダウンロード数: 201

このアイテムのファイル:
ファイル 記述 サイズフォーマット 
fsn3.366.pdf178.56 kBAdobe PDF見る/開く
タイトル: Piceatannol exhibits anti-inflammatory effects on macrophages interacting with adipocytes
著者: Yamamoto, Takayuki
Li, Yongjia
Hanafusa, Yuki
Yeh, Yu Sheng
Maruki-Uchida, Hiroko
Kawakami, Shinpei
Sai, Masahiko
Goto, Tsuyoshi  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0003-1283-147X (unconfirmed)
Ito, Tatsuhiko
Kawada, Teruo
著者名の別形: 河田, 照雄
後藤, 剛
キーワード: 3T3-L1 Adipocytes
C3H10T1/2 adipocytes
inflammation
piceatannol
RAW264.7 macrophages
UCP1
発行日: 6-Jan-2017
出版者: Wiley-Blackwell
誌名: Food Science and Nutrition
巻: 5
号: 1
開始ページ: 76
終了ページ: 85
抄録: Piceatannol (PIC), a natural analog of resveratrol (RES), is a phytochemical found in passion fruit seeds. To clarify the effects of PIC on obesity-induced inflammation in adipose tissue, we investigated the anti-inflammatory activity of PIC-related compounds (PIC, RES, and metabolites from PIC) in culture models of obese adipose tissue. Lipopolysaccharide (LPS) and conditioned medium from 3T3-L1 adipocytes (3T3-L1-CM) enhanced proinflammatory gene expression and synthesis of nitric oxide (NO), tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6) in RAW264.7 macrophages. Although each compound inhibited the mRNA expression of iNOS (inducible NO synthase), TNF-α, and IL-6, PIC potently inhibited them, and 30 μmol/L PIC suppressed the LPS- and 3T3-L1-CM-induced mRNA expression of iNOS (70.4% and 69.2% suppression, respectively), TNF-α (42.6% and 47.0% suppression), and IL-6 (27.3% and 42.1% suppression). PIC also significantly suppressed production of NO (80.3% suppression) and inflammatory cytokines (TNF-α; 33.7% suppression, IL-6; 66.5% suppression). Furthermore, PIC was found to rescue the uncoupling protein 1 mRNA expression induced by isoproterenol in 10T1/2 adipocytes, which was suppressed by LPS-activated macrophages. These results suggest that PIC may attenuate the pathologic inflammation triggered by adipose tissues.
著作権等: © 2016 The Authors. Food Science & Nutrition published by Wiley Periodicals, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
URI: http://hdl.handle.net/2433/218315
DOI(出版社版): 10.1002/fsn3.366
PubMed ID: 28070318
出現コレクション:学術雑誌掲載論文等

アイテムの詳細レコードを表示する

Export to RefWorks


出力フォーマット 


このリポジトリに保管されているアイテムはすべて著作権により保護されています。