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タイトル: | Piceatannol exhibits anti-inflammatory effects on macrophages interacting with adipocytes |
著者: | Yamamoto, Takayuki Li, Yongjia Hanafusa, Yuki Yeh, Yu Sheng Maruki-Uchida, Hiroko Kawakami, Shinpei Sai, Masahiko Goto, Tsuyoshi https://orcid.org/0000-0003-1283-147X (unconfirmed) Ito, Tatsuhiko Kawada, Teruo |
著者名の別形: | 河田, 照雄 後藤, 剛 |
キーワード: | 3T3-L1 Adipocytes C3H10T1/2 adipocytes inflammation piceatannol RAW264.7 macrophages UCP1 |
発行日: | 6-Jan-2017 |
出版者: | Wiley-Blackwell |
誌名: | Food Science and Nutrition |
巻: | 5 |
号: | 1 |
開始ページ: | 76 |
終了ページ: | 85 |
抄録: | Piceatannol (PIC), a natural analog of resveratrol (RES), is a phytochemical found in passion fruit seeds. To clarify the effects of PIC on obesity-induced inflammation in adipose tissue, we investigated the anti-inflammatory activity of PIC-related compounds (PIC, RES, and metabolites from PIC) in culture models of obese adipose tissue. Lipopolysaccharide (LPS) and conditioned medium from 3T3-L1 adipocytes (3T3-L1-CM) enhanced proinflammatory gene expression and synthesis of nitric oxide (NO), tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6) in RAW264.7 macrophages. Although each compound inhibited the mRNA expression of iNOS (inducible NO synthase), TNF-α, and IL-6, PIC potently inhibited them, and 30 μmol/L PIC suppressed the LPS- and 3T3-L1-CM-induced mRNA expression of iNOS (70.4% and 69.2% suppression, respectively), TNF-α (42.6% and 47.0% suppression), and IL-6 (27.3% and 42.1% suppression). PIC also significantly suppressed production of NO (80.3% suppression) and inflammatory cytokines (TNF-α; 33.7% suppression, IL-6; 66.5% suppression). Furthermore, PIC was found to rescue the uncoupling protein 1 mRNA expression induced by isoproterenol in 10T1/2 adipocytes, which was suppressed by LPS-activated macrophages. These results suggest that PIC may attenuate the pathologic inflammation triggered by adipose tissues. |
著作権等: | © 2016 The Authors. Food Science & Nutrition published by Wiley Periodicals, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
URI: | http://hdl.handle.net/2433/218315 |
DOI(出版社版): | 10.1002/fsn3.366 |
PubMed ID: | 28070318 |
出現コレクション: | 学術雑誌掲載論文等 |
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