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タイトル: | Chromatin Remodeling and Transcriptional Control in Innate Immunity: Emergence of Akirin2 as a Novel Player |
著者: | Tartey, Sarang Takeuchi, Osamu https://orcid.org/0000-0002-1260-6232 (unconfirmed) |
著者名の別形: | 竹内, 理 |
キーワード: | macrophage innate immunity inflammation transcriptional regulation chromatin remodeling NF-κB |
発行日: | 22-Jul-2015 |
出版者: | MDPI AG |
誌名: | Biomolecules |
巻: | 5 |
号: | 3 |
開始ページ: | 1618 |
終了ページ: | 1633 |
抄録: | Transcriptional regulation of inflammatory gene expression has been at the forefront of studies of innate immunity and is coordinately regulated by transcription factors, including NF-κB, and chromatin modifiers. The growing evidence for involvement of chromatin in the regulation of gene expression in innate immune cells, has uncovered an evolutionarily conserved role of microbial sensing and chromatin remodeling. Toll-like receptors and RIG-I-like receptors trigger these signaling pathways leading to transcriptional expression of a set of genes involved in inflammation. Tightly regulated control of this gene expression is a paramount, and often foremost, goal of most biological endeavors. In this review, we will discuss the recent progress about the molecular mechanisms governing control of pro-inflammatory gene expression by an evolutionarily conserved novel nuclear protein Akirin2 in macrophages and its emergence as an essential link between NF-κB and chromatin remodelers for transcriptional regulation. |
著作権等: | © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). |
URI: | http://hdl.handle.net/2433/218623 |
DOI(出版社版): | 10.3390/biom5031618 |
PubMed ID: | 26287257 |
出現コレクション: | 学術雑誌掲載論文等 |
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