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タイトル: | An analysis of the structure of the compound biological effectiveness factor |
著者: | Ono, Koji |
著者名の別形: | 小野, 公二 |
キーワード: | CBE factor BPA BSH radiation myelopathy dermal necrosis radiation pneumonitis |
発行日: | 16-Aug-2016 |
出版者: | Oxford University Press (OUP) |
誌名: | Journal of Radiation Research |
巻: | 57 |
号: | S1 |
開始ページ: | i83 |
終了ページ: | i89 |
抄録: | This report is an analysis of the structure of the compound biological effectiveness (CBE) factor. The value of the CBE factor previously reported was revalued for the central nervous system, skin and lung. To describe the structure, the following terms are introduced: the vascular CBE (v-CBE), intraluminal CBE (il-CBE), extraluminal CBE (el-CBE) and non-vascular CBE (nv-CBE) factors and the geometric biological factor (GBF), i.e. the contributions that are derived from the total dose to the vasculature, each dose to vasculature from the intraluminal side and the extraluminal side, the dose to the non-vascular tissue and the factor to calculate el-CBE from il-CBE, respectively. The el-CBE factor element was also introduced to relate il-CBE to el-CBE factors. A CBE factor of 0.36 for disodium mercaptoundecahydrododecaborate (BSH) for the CNS was independent of the 10B level in the blood; however, that for p-Boron-L-phenylalanine (BPA) increased with the 10B level ratio of the normal tissue to the blood (N/B). The CBE factor was expressed as follows: factor = 0.32 + N/B × 1.65. The factor of 0.32 at 0 of N/B was close to the CBE factor for BSH. GBFs had similar values, between BSH and BPA, 1.39 and 1.52, respectively. The structure of the CBE factor for BPA to the lung was also elucidated based on this idea. The factor is described as follows: CBE factor = 0.32 + N/B × 1.80. By this elucidation of the structure of the CBE factor, it is expected that basic and clinical research into boron neutron capture therapy will progress. |
著作権等: | © 2016 The Author 2016. Published by Oxford University Press on behalf of The Japan Radiation Research Society and Japanese Society for Radiation Oncology. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( http://creativecommons.org/licenses/by-nc/4.0/ ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. |
URI: | http://hdl.handle.net/2433/219639 |
DOI(出版社版): | 10.1093/jrr/rrw022 |
PubMed ID: | 27021218 |
出現コレクション: | 学術雑誌掲載論文等 |
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