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ファイル | 記述 | サイズ | フォーマット | |
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j.bbrc.2009.07.052.pdf | 1.46 MB | Adobe PDF | 見る/開く |
タイトル: | The effects of cardioactive drugs on cardiomyocytes derived from human induced pluripotent stem cells |
著者: | Yokoo, Noritaka Baba, Shiro Kaichi, Shinji Niwa, Akira Mima, Takahiro Doi, Hiraku Yamanaka, Shinya Nakahata, Tatsutoshi Heike, Toshio |
著者名の別形: | 横尾, 憲孝 平家, 俊男 山中, 伸弥 |
キーワード: | Arrhythmia Cardiomyocytes Drug loading test Human embryonic stem cell Human induced pluripotent stem cell |
発行日: | Sep-2009 |
出版者: | Elsevier |
誌名: | Biochemical and Biophysical Research Communications |
巻: | 387 |
号: | 3 |
開始ページ: | 482 |
終了ページ: | 488 |
抄録: | Developing effective drug therapies for arrhythmic diseases is hampered by the fact that the same drug can work well in some individuals but not in others. Human induced pluripotent stem (iPS) cells have been vetted as useful tools for drug screening. However, cardioactive drugs have not been shown to have the same effects on iPS cell-derived human cardiomyocytes as on embryonic stem (ES) cell-derived cardiomyocytes or human cardiomyocytes in a clinical setting. Here we show that current cardioactive drugs affect the beating frequency and contractility of iPS cell-derived cardiomyocytes in much the same way as they do ES cell-derived cardiomyocytes, and the results were compatible with empirical results in the clinic. Thus, human iPS cells could become an attractive tool to investigate the effects of cardioactive drugs at the individual level and to screen for individually tailored drugs against cardiac arrhythmic diseases. |
著作権等: | c 2009 Elsevier Inc. All rights reserved. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 This is not the published version. Please cite only the published version. |
URI: | http://hdl.handle.net/2433/85222 |
DOI(出版社版): | 10.1016/j.bbrc.2009.07.052 |
PubMed ID: | 19615974 |
出現コレクション: | 学術雑誌掲載論文等 |
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