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タイトル: | Psychological stress activates a dorsomedial hypothalamus-medullary raphe circuit driving brown adipose tissue thermogenesis and hyperthermia. |
著者: | Kataoka, Naoya Hioki, Hiroyuki Kaneko, Takeshi Nakamura, Kazuhiro |
著者名の別形: | 片岡, 直也 中村, 和弘 |
発行日: | 5-Aug-2014 |
誌名: | Cell metabolism |
巻: | 20 |
号: | 2 |
開始ページ: | 346 |
終了ページ: | 358 |
抄録: | Psychological stress-induced hyperthermia (PSH) is a fundamental autonomic stress response observed in many mammalian species. Here we show a hypothalamomedullary, glutamatergic neural pathway for psychological stress signaling that drives the sympathetic thermogenesis in brown adipose tissue (BAT) that contributes to PSH. Using in vivo drug nanoinjections into rat brain and thermotelemetry, we demonstrate that the rostral medullary raphe region (rMR) and dorsomedial hypothalamus (DMH) mediate a psychosocial stress-induced thermogenesis in BAT and PSH. Functional neuroanatomy indicates that the DMH functions as a hub for stress signaling, with monosynaptic projections to the rMR for sympathetic outputs and to the paraventricular hypothalamic nucleus for neuroendocrine outputs. Optogenetic experiments showed that the DMH-rMR monosynaptic pathway drives BAT thermogenesis and cardiovascular responses. These findings make an important contribution to our understanding of the central autonomic circuitries linking stress coping with energy homeostasis-potentially underlying the etiology of psychogenic fever, a major psychosomatic symptom. |
記述: | 心理ストレスを受けたときに体温を上昇させる脳神経回路を解明 -ストレス疾患の発症機構の解明に期待- 京都大学プレスリリース. 2014-06-27. |
著作権等: | © 2014 Elsevier Inc. NOTICE: this is the author's version of a work that was accepted for publication in Cell Metabolism. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Cell metabolism: 20(2) 346–358, 2014, doi:10.1016/j.cmet.2014.05.018 This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 |
URI: | http://hdl.handle.net/2433/194291 |
DOI(出版社版): | 10.1016/j.cmet.2014.05.018 |
PubMed ID: | 24981837 |
関連リンク: | http://www.kyoto-u.ac.jp/ja/news_data/h/h1/news6/2014/140627_1.htm |
出現コレクション: | 学術雑誌掲載論文等 |
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