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bs.enz.2022.08.005.pdf | 1.01 MB | Adobe PDF | 見る/開く |
タイトル: | Chapter Five: DNA damage and biological responses induced by Boron Neutron Capture Therapy (BNCT) |
著者: | Kondo, Natsuko ![]() ![]() |
著者名の別形: | 近藤, 夏子 |
キーワード: | BNCT DNA damage double strand breaks (DSBs) DNA repair Biological effects |
発行日: | 2022 |
出版者: | Elsevier BV |
誌名: | The Enzymes |
巻: | 51 |
開始ページ: | 65 |
終了ページ: | 78 |
抄録: | Boron Neutron Capture Therapy (BNCT) is a tumor cell selective high LET (linear energy transfer) particle beam therapy. The patient is administrated a boron (¹⁰B) compound via intravenous injection or infusion, and when ¹⁰B is sufficiently accumulated in the tumor, neutron beams containing epithermal neutrons as the main component are irradiated. Epithermal neutrons lose energy in the body and become thermal neutrons. The captured ¹⁰B undergoes a (n, α) reaction with thermal neutrons, and the resulting α particles and ⁷Li nuclei have short ranges of 9-10 μm and 4-5 μm, respectively, and do not reach the surrounding cells in normal tissues. Therefore, these high LET-heavy charged particles can selectively kill cancer cells. The cell-killing effect of these heavy charged particles is thought to be triggered by DNA damage. It is known that DNA damage caused by heavy charged particles is more serious and difficult to repair than DNA damage caused by Low LET radiation such as X-rays and γ-rays. This review focuses on DNA damage, e.g., DNA strand breaks and DNA damage repair caused by BNCT and describes the resulting biological response. |
記述: | DNA Damage and Double Strand Breaks -Part A |
著作権等: | © 2022. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/ This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 This article is deposited under the publisher's permission. 発行元の許可を得て登録しています. |
URI: | http://hdl.handle.net/2433/287531 |
DOI(出版社版): | 10.1016/bs.enz.2022.08.005 |
PubMed ID: | 36336409 |
出現コレクション: | 学術雑誌掲載論文等 |
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