DSpace コレクション: 1998-031998-03http://hdl.handle.net/2433/1151552024-03-28T16:43:49Z2024-03-28T16:43:49Z腎癌患者における尿中インターロイキン1β, インターロイキン6, 腫瘍壊死因子-αの検討石, 冰冰中沢, 速和龍治, 修合谷, 信行伊藤, 文夫古賀, 祥嗣奥田, 比佐志小林, 博人東間, 紘http://hdl.handle.net/2433/1161512021-09-15T09:59:17Z1998-03-01T00:00:00Zタイトル: 腎癌患者における尿中インターロイキン1β, インターロイキン6, 腫瘍壊死因子-αの検討
著者: 石, 冰冰; 中沢, 速和; 龍治, 修; 合谷, 信行; 伊藤, 文夫; 古賀, 祥嗣; 奥田, 比佐志; 小林, 博人; 東間, 紘
抄録: 1)腎細胞癌患者の腎癌摘除前尿中IL-1β濃度は進行度や組織異型度による差はなく, 又, 対照群に比べて有意差を認めなかった.腎細胞癌患者の術後尿中IL-1β濃度は有意に上昇したが, 一定の傾向は認めなかった. 2)腎細胞癌患者の尿中IL-6とTNF-αは術前後とも測定可能例が少なく, 対照群に比べ有意差を認めなかった.以上より尿中IL-1β, IL-6, TNF-αの測定は腎細胞癌の診断に臨床的有用性は低いと考えられた; We examined the preoperative and postoperative, urinary levels of the cytokines, interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) in 14 patients with renal cell carcinoma (RCC), and 9 patients who underwent nephrectomy as donors (controls). Although urinary IL-1 beta was measurable in every subject, both IL-6 and TNF-alpha were undetectable in 12 of the 14 patients. None of the urinary cytokines showed levels significantly different from the controls preoperatively. Urinary levels of IL-1 beta showed no correlation with clinical stage or histological grade. Only urinary IL-1 beta was significantly elevated after nephrectomy, when compared with the controls (P < 0.05). However, urinary IL-1 beta showed no correlation with operative blood loss or postoperative infection. These findings suggest that measurement of urinary cytokines is not useful for diagnosis or monitoring of therapy in RCC patients.1998-03-01T00:00:00Z局所浸潤膀胱癌に対する放射線及び化学療法を主体とした膀胱温存療法の長期予後について野口, 純男高瀬, 和紀窪田, 吉信増田, 光伸矢尾, 正祐穂坂, 正彦http://hdl.handle.net/2433/1161502021-09-15T09:59:18Z1998-03-01T00:00:00Zタイトル: 局所浸潤膀胱癌に対する放射線及び化学療法を主体とした膀胱温存療法の長期予後について
著者: 野口, 純男; 高瀬, 和紀; 窪田, 吉信; 増田, 光伸; 矢尾, 正祐; 穂坂, 正彦
抄録: 膀胱温存療法が施行された局所浸潤膀胱癌54症例を対象に検討した. 1)局所浸潤膀胱癌に対する膀胱温存療法施行症例は膀胱全摘除術施行症例と比較して有意に高齢者に多く施行されていた.又, cause-specific survivalでは有意に予後不良であった. 2)局所浸潤膀胱に対する膀胱温存療法施行症例の予後を不良としている背景因子は単変量解析では腫瘍の大きさ, 水腎症の有無, 腫瘍のgrade, PSの4項目であり, 多変量解析では腫瘍のgradeに最も重みが存在した. 3)5年以上生存例は17例であったが, PS 0, 1が78%であった.又, 5年から10年の間に癌死した症例が4例存在し, 他に癌あり生存中が2例存在し, これらは全てG3症例であった; The prognoses and prognostic factors of the 54 patients with locally invasive bladder cancer who underwent bladder preservation therapy at Yokohama City University Hospital between 1977 and 1995 were analyzed statistically. The therapeutic modalities of bladder preservation were mainly radiation or chemotherapy. The prognosis for the patients who underwent bladder preservation therapy was worse than that for the patients who underwent total cystectomy. The prognostic factors of these patients were size and grade of tumor, presence of hydronephrosis and performance status (PS) of the patients by univariate analysis. Tumor grade was the most predictable prognostic factor using multivariate analysis. Only 17 patients survived more than 5 years after treatment; 78% of the survivors had good PS (0 or 1). Five of them died of cancer and two patients were alive with cancer. All of them had G3 tumors. These results suggest that patients with locally invasive G2 tumor could be candidates for bladder preservation therapy and patients who underwent bladder preservation therapy should be evaluated at 10 years post-therapy.1998-03-01T00:00:00Z東葛病院におけるProstate specific antigen(PSA)単独前立腺癌検診の試行 : 経過観察脱落者の検討清水, 信明山中, 英寿一ノ瀬, 義雄斎藤, 佳隆http://hdl.handle.net/2433/1161492021-09-15T09:59:18Z1998-03-01T00:00:00Zタイトル: 東葛病院におけるProstate specific antigen(PSA)単独前立腺癌検診の試行 : 経過観察脱落者の検討
著者: 清水, 信明; 山中, 英寿; 一ノ瀬, 義雄; 斎藤, 佳隆
抄録: 前立腺検査受診者550人中前立腺癌患者は11人であった.PSA高値で経過観察必要群として翌年PSA測定を試みたが測定し得たのは47人中33人であった.経過観察できなかった14人の理由では現在困っていないが8人で最も多かった.QOLスコアは, 経過観察可能群では2.6±1.6, 経過観察不能群では1.7±1.0, I-PSS合計点数は経過観察可能群では11.3±7.1, 経過観察不能群では6.0±4.1であった; We studied the usefulness of prostate cancer screening using prostate specific antigen (PSA) and PSA density (PSAD). In the first year of this screening (1995), we detected prostate cancer in 11 out of 550 (1.7%) subjects. Only 33 of the 47 (70%) subjects whose PSA values were greater than the cut-off value could be followed the following year. The remaining 14 subjects could not be followed mainly because of absence of urination difficulty at that time. The international prostate symptom score (I-PSS) sum and the quality of life (QOL) score at the screening in the unfollowed group were significantly lower than those in the followed group. The subjects who must be followed and whose QOL score and I-PSS sum are low at the time of screening need more careful and persuasive explanation from the urologist on the importance of long-term follow-up.1998-03-01T00:00:00Z腎被膜より発生した悪性線維性組織球腫の自然破裂の1例米本, 洋次岡, 伸俊水野, 禄仁大前, 博志http://hdl.handle.net/2433/1161482021-09-15T09:59:18Z1998-03-01T00:00:00Zタイトル: 腎被膜より発生した悪性線維性組織球腫の自然破裂の1例
著者: 米本, 洋次; 岡, 伸俊; 水野, 禄仁; 大前, 博志
抄録: 症例は50歳男で, 右側腹痛と発熱を主訴とする.近医での腹部CTにて右腎部にspace-occupying lesion(SOL)を認めたため, 当院に入院となった.CTにて右腎上極に7×9×10cmの不均一なSOLを認めた.選択的右腎動脈造影により, 右腎上極に直径8cmのavascular lesionを認め, 腎被膜動脈は外側に伸展されていた.右腎腫瘍の自然破裂と診断し, 経腹的根治的右腎摘出術を施行した.組織学的診断は腎被膜を母体とした悪性線維性組織球腫であった; We report a case of spontaneous rupture of malignant fibrous histiocytoma. A 50-year-old male with right flank pain was referred to our hospital. Computed tomography (CT) showed a heterogeneous space-occupying lesion on the upper pole of the right kidney. Selective right renal arteriography revealed a hypovascular mass. Preoperative clinical diagnosis was spontaneous rupture of renal cell carcinoma. Radical nephrectomy was performed. Histopathological diagnosis was malignant fibrous histiocytoma arising from the renal capsule.1998-03-01T00:00:00Z