DSpace コレクション: 1991-091991-09http://hdl.handle.net/2433/1163532024-03-29T10:39:54Z2024-03-29T10:39:54Z第39回日本泌尿器科学会中部総会シンポジウム1: 「尿路感染症発症についての諸問題」 女子急性単純性膀胱炎の臨床的研究兼松, 稔林, 秀治永井, 司加藤, はる山田, 伸一郎山本, 直樹高橋, 義人石原, 哲山羽, 正義武田, 明久藤広, 茂栗山, 学坂, 義人河田, 幸道http://hdl.handle.net/2433/1172982021-09-15T09:51:57Z1991-09-01T00:00:00Zタイトル: 第39回日本泌尿器科学会中部総会シンポジウム1: 「尿路感染症発症についての諸問題」 女子急性単純性膀胱炎の臨床的研究
著者: 兼松, 稔; 林, 秀治; 永井, 司; 加藤, はる; 山田, 伸一郎; 山本, 直樹; 高橋, 義人; 石原, 哲; 山羽, 正義; 武田, 明久; 藤広, 茂; 栗山, 学; 坂, 義人; 河田, 幸道
抄録: 1989年3月31日までの1年間に, 受診した499例について, 1)患者の年齢分布は3歳~88歳(平均年齢43歳)で, 20歳代が24%を占め最も多かったが, 30歳代から60歳代にかけても14~16%の年齢分布を示した.2)尿からの分離菌種はE. coliが圧倒的に多く(81%), ついで各種のStaphylococcus spp. (11%)が多かった.Staphylococcus spp.は夏期に多く分離される傾向があった.3)臨床症状として80%以上の症例が排尿痛, 残尿感, 頻尿を訴え, 初発症状として最も多いのは排尿痛(39%)であった.4)患者の訴えによる膀胱炎発症の誘因としては, 過労(131例), 排尿我慢(114例), 冷え(103例)が多く, 性交渉が発症誘因と回答したのは42例であった.5)「新婚膀胱炎」を経験した患者群は, 経験しない患者群に比べて, 最近3年以内の膀胱炎罹患率が有意に高かった; A total of 499 female patients with acute uncomplicated cystitis were observed and analyzed clinically for age distribution, characteristics of symptoms, bacterial culture of urine, behavioral aspects of recurrent cystitis and others. The patients were between 3 years and 88 years old (average: 43 years) and the majority of patients were from 20 to 69 years old. From 81.1% of the patients Escherichia coli was detected, followed by Staphylococcus spp (11.2%). The major symptoms were pain on urination (421 cases), urinary frequency (421 cases) and residual urine sensation (418 cases). The major causes of cystitis as reported by the patient were fatigue (131 cases), infrequent voiding (114 cases) and exposing the body to coldness (103); only 42 patients reported a relationship between sexual intercourse and cystitis. The patients who had been suffering from "honeymoon cystitis" were significantly inclined to be suffering from acute uncomplicated cystitis again in comparison with those who had not suffered from honeymoon cystitis. There was suggested to be a relationship between sexual intercourse and recurrent cystitis.1991-09-01T00:00:00Z尿路感染症における大腸菌の線毛の役割について石川, 成明http://hdl.handle.net/2433/1172972021-09-15T09:51:57Z1991-09-01T00:00:00Zタイトル: 尿路感染症における大腸菌の線毛の役割について
著者: 石川, 成明
抄録: 1)腎盂腎炎患者由来株では膀胱炎患者由来株よりもP線毛保有率が高かった.2) P線毛保有菌の大部分は1型線毛も有していた.3) P線毛保有菌は1型線毛保有菌よりも尿路上皮細胞に親和性が高かった.4)いずれの型の線毛保有菌も腎盂, 尿管, 膀胱上皮細胞ではその親和性に差はみられなかった; The incidence of P-fimbriated E. coli from patients with pyelonephritis, cystitis and asymptomatic bacteriuria was 78.6%, 31.9% and 22.2%, respectively. Almost all of the P-fimbriated E. coli have also type-1 fimbriae. In the in vitro test, P-fimbriated E. coli attached to the uroepithelial cells in higher number than the type 1 fimbriated E. coli. The results of the adhesion inhibition test suggested that simultaneous presence of P-and type 1 fimbriae is the most significant virulence factor in urinary tract infections.1991-09-01T00:00:00Z尿路感染発症における尿流停滞の意義荒川, 創一中田, 勝久守殿, 貞夫http://hdl.handle.net/2433/1172962021-09-15T09:51:58Z1991-09-01T00:00:00Zタイトル: 尿路感染発症における尿流停滞の意義
著者: 荒川, 創一; 中田, 勝久; 守殿, 貞夫
抄録: 尿路感染発症の因子としての尿流停滞の意義について, 基礎的および臨床的に検討した.1)無処置および糖尿病マウスの上行性腎盂腎炎モデルにおいて, 膀胱内菌液接種後外尿道口クランプ時間が長くなるほどそのID50値は低下し, 膀胱内尿停滞による易感染化が示された.2)前立腺術後6ヵ月以内におこったUTIについて, 残尿あり, 残尿なしの2群に分け, その起炎菌種の内訳, 膿尿, 細菌尿の程度を検討したところ, 前者で複数菌感染がやや多かったが, その他の項目で差はなかった.3)上記2群にセフェム系抗菌薬を投与しその薬効を比べたところ, 両群に差はなかった.以上の結果から, 尿流停滞は易感染因子と考えられたが, 治療上は残尿という因子に限っていえば難治因子とはなっていないことが明らかとなった; A basic and clinical study was made on the significance of stagnancy of urinary flow as a factor causing urinary tract infections. A bacterial solution was inoculated into the bladder of untreated and diabetic mice with model ascending pyelonephritis. The longer the external urethral opening was clamped, the lower became the value of ID50, thus showing infection easily caused by urinary stagnancy in the bladder. Patients who had UTI within 6 months after prostatic operation were divided into two groups, one with residual urine and the other without residual urine. Then, the type of the causative organism, and the severity of pyuria and bacteriuria were determined. In the former, there were slightly more patients with infection caused by plural bacteria. However, no other differences were observed. The administration of cephem antibiotics revealed no differences in effectiveness between the two groups. In conclusion, stagnancy of urinary flow has been considered a factor easily causing infection. However, so far as residual urine is concerned, it is not an intractable factor in treatment.1991-09-01T00:00:00Z腎結石を基礎とする腎孟腎炎について抗菌力の異なった薬剤による化学療法の反応の差異に基づいた「局所抗菌力係数」の概念 - (局所抗菌力係数の想定の試み)鈴木, 恵三堀場, 優樹長田, 恵弘名出, 頼男http://hdl.handle.net/2433/1172952021-09-15T09:51:58Z1991-09-01T00:00:00Zタイトル: 腎結石を基礎とする腎孟腎炎について抗菌力の異なった薬剤による化学療法の反応の差異に基づいた「局所抗菌力係数」の概念 - (局所抗菌力係数の想定の試み)
著者: 鈴木, 恵三; 堀場, 優樹; 長田, 恵弘; 名出, 頼男
抄録: In the treatment of one male patient with chronic pyelonephritis, complicated with renal stone, the pathological state of the renal inflammatory lesion was determined. The patient had been persistently infected by the same strain of S. marcescens for more than a year. When he was treated by several antimicrobial agents, the urinary bacteriological response was well correlated to the MICs of each agent. On the basis of the findings obtained, a new index of local antimicrobial activity was proposed. Analysis of such items as strains appearing after treatment, interval of relapse and the identification of the strains relapsed, were suggestive of the renal inflammatory, and pathological conditions. The clinical response also correlated well with the index. The lesion was considered to be mainly localized in the right lower calyx where a tiny stone existed. This disease is considered curable with effective chemotherapy after withdrawal of the stone. This index should be useful for evaluation of the effectiveness of antimicrobial agents.1991-09-01T00:00:00Z