DSpace コレクション: 1980-03
http://hdl.handle.net/2433/121043
1980-032024-03-28T11:58:13Zヒト腎細胞癌の基礎的研究 第5報 : ヒト腎細胞癌に由来する細胞株OUR-10の性質について
http://hdl.handle.net/2433/122617
タイトル: ヒト腎細胞癌の基礎的研究 第5報 : ヒト腎細胞癌に由来する細胞株OUR-10の性質について
著者: 松田, 稔; 長船, 匡男; 中野, 悦次; 石橋, 道男; 古武, 敏彦; 園田, 孝夫; 渡辺, 信一郎; 波田, 寿一; 大河内, 寿一; 東野, 一彌; 山村, 雄一; 平岡, 諦
抄録: A cell line, designated as OUR-10, was established from a human renal cell carcinoma. This cell line have been maintained for more than 28 months with a passage of I week interval. Under inverted microscopy, confluent monolayer of the OUR-10 was composed mainly with polygonal epithelial cells with small round cells or dendritic cells and characterized by the abscence of contact inhibition. With electron microscopy, differentiated cell surface structure looking like microvilli, which was a characteristic fine structure of the human renal cell carcinoma cells, were cbserved. Karyological analysis revealed hypodiploid modal chromosome numbers of 39 and 40. Marker chromosomes with obvious structural anomalies were not detected but non-random loss of three chromosomes in Group D and one in Group E were recognized. The doubling time was approximately 32 hours at the 50th generation. The cells could not form proliferating nodules in the back of the nude mice, even pretreated with cyclophosphamide or X-ray irradiation. But heterotransplantation into the cheek pouch of immunosuppressed hamsters formed tumors, which showed impressive similarity to the original cancer on histology. To clarify the origin of the cell line, several enzymological studies were performed and the T-GTP isozyme contained in the cell line was confirmed to be the same with the novel isozyme detected in about a half of the renal carcinoma tissues. Genetic phenotype of the G6PD was identified as B, and the HLA antigenic structure was A2, II; B5, 40, which were clearly different from the characters of HeLa cells.1980-03-01T00:00:00Z膀胱癌患者における血清蛋白の変動
http://hdl.handle.net/2433/122616
タイトル: 膀胱癌患者における血清蛋白の変動
著者: 久住, 治男; 中鳴, 和喜; 塚原, 健治; 黒田, 恭一; 右田, 俊介
抄録: Using a micro-single radial immuncdifusion method, quantitative studies have been made on the serum proteins of bladder cancer patients; 11 patients in the early stage of tumors and 17 patients m the advanced stage. In the early group, 12 proteins (α1AT, α1X, Hp, Cp, IgG, β2III , β2I, IgA, Znα2, C9, C5, βLP) were significantly elevated. In the advanced group, 14 proteins (α1AT, α1AG, α1a, X, Znα2, Hp, Cp, C9, CP3A, C5, β2IIl, C4, βLp, ClsI, IgA) significantly increased and 6 proteins (Pre, Alb, α2HS, α2M, Tf, Pm) significantly decreased. This group showed a significant increase of C9, α1AG and C3PA and a significant decrease of Pre, Alb, α2HS, α2M and Tf as compared with the early stage group. It was assumed that these alterations have a possible usefulness in estimating the stage of tumors or prognosis of disease. There was a significant correlation between C9 andα1AT in all the 28 patients. A possible clinical significance of the alterations of the complement, coagulation, and fibrinolysis systems in cancer patients is mainly discussed.1980-03-01T00:00:00Z腎癌の臨床 --臨床症状,臨床検査成績と予後との関係,および転移を有する症例について--
http://hdl.handle.net/2433/122615
タイトル: 腎癌の臨床 --臨床症状,臨床検査成績と予後との関係,および転移を有する症例について--
著者: 岩崎, 卓夫; 川村, 寿一; 吉田, 修
抄録: One hundred and twenty-three cases of renal cell carcinoma, treated at Department of Urology, Kyoto University Hospital during January 1955 through December 1977 were reviewed. 1. As the patients were classified according to Holland's classification, twelve cases were stage I, nineteen cases stage II, fifty-three cases stage III, twenty-two cases stage IV, and seventeen cases unclassified. 2. Overall relative survival rate at one year, three year, five year, ten year were 72%, 50%, 46%, 34% respectively. 3. The most common symptom was macroscopic hematuria, and followed by pain, fever, weight loss, fatigue and plapable mass. 4. Relative survival rate of the patients who showed macroscopic hematuria was better than that of the patients who did not show macroscopic hematuria. Relative survival rate of the patients who did not have palpable abdominal mass was better than that of the patients who had palpable abdominal mass. The presence of pain or fever did not alter the survival rate. 5. As for the laboratory findings, elevation of erythrocyte sedimentation rate was most common, followed by positive C-reactive protein, elevation of alkaline phosphatase value, elevation of lactic dehydrogenase value, and serum Ca elevation. 6. The relative survival rate of the patients who showed normal erythrocyte sedimentation rate or alkaline phosphatase value were better than the patients who showed abnoraml erythrocyte sedimentation rate or alkaline phosphatase value. The higher the erythrocyte sedimentation rate showed, the poorer the relative survival rate of the patient. 7. The site of distant metastasis was most common in lung, followed by bone, lymph node and liver. The patients with bone metastasis lived longer than the patients with lung metastasis. 8. No remarkable difference was seen between the survival rate of the patients treated by nephrectomy alone and nephrectomy plus adjuvant therapy.1980-03-01T00:00:00Z人工透析に関する臨床的研究(第4報) - 免疫学的検討 -
http://hdl.handle.net/2433/122614
タイトル: 人工透析に関する臨床的研究(第4報) - 免疫学的検討 -
著者: 細川, 進一; 坂口, 昇; 友吉, 唯夫; 長尾, 昌寿; 西尾, 利一
抄録: Immunological examinations were made on 9 patients under maintenance hemodialysis. Nine patients consisted of 5 men and 4 women. They are on the regular hemodialysis schedule, 3 times a week and 5 hours per each. The hemodialysis apparatus used are variable such as hollow fiber and coil form etc. IgG, IgA, IgM and complement C3c and C4 were determined. For determination of IgG, IgA, IgM, Tri-Partigen kit of Behring Werke Company, and for C3c and C4, M-Partigen kit of the same company. IgG was low in 2 cases. Only one case showed the depression of the value of IgA. IgM was low in 2 cases. (C3c(β1 A-globulin) was low in all the cases. C4(β1 E-globulin) was low in 5 cases.1980-03-01T00:00:00Z