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dc.contributor.author | Kanai, Masashi | en |
dc.contributor.author | Yoshioka, Akira | en |
dc.contributor.author | Tanaka, Shiro | en |
dc.contributor.author | Nagayama, Satoshi | en |
dc.contributor.author | Matsumoto, Shigemi | en |
dc.contributor.author | Nishimura, Takafumi | en |
dc.contributor.author | Niimi, Miyuki | en |
dc.contributor.author | Teramukai, Satoshi | en |
dc.contributor.author | Takahashi, Ryo | en |
dc.contributor.author | Mori, Yukiko | en |
dc.contributor.author | Kitano, Toshiyuki | en |
dc.contributor.author | Ishiguro, Hiroshi | en |
dc.contributor.author | Yanagihara, Kazuhiro | en |
dc.contributor.author | Chiba, Tsutomu | en |
dc.contributor.author | Fukushima, Masanori | en |
dc.contributor.author | Matsuda, Fumihiko | en |
dc.contributor.alternative | 金井, 雅史 | ja |
dc.date.accessioned | 2010-05-11T01:41:01Z | - |
dc.date.available | 2010-05-11T01:41:01Z | - |
dc.date.issued | 2010-04 | - |
dc.identifier.issn | 1877-7821 | - |
dc.identifier.uri | http://hdl.handle.net/2433/109963 | - |
dc.description.abstract | PURPOSE: Although the risk of oxaliplatin-induced neuropathy depends on cumulative oxaliplatin dose, susceptibility to this adverse event differs greatly among patients. In this study, we investigated the associations between oxaliplatin-induced neuropathy and the following polymorphisms: glutathione S-transferase pi (GSTP1) Ile(105)Val, and glyoxylate aminotransferase (AGXT) Pro(11)Leu and AGXT Ile(340)Met. EXPERIMENTAL DESIGN: Eighty-two Japanese patients with histologically confirmed colorectal cancer who received at least six cycles of the modified FOLFOX6 (m-FOLFOX6) regimen were enrolled. To minimize differences in cumulative oxaliplatin dose between patients, oxaliplatin-induced neuropathy was evaluated using an oxaliplatin-specific scale during the 2-week period after completion of the sixth cycle of treatment. RESULTS: Forty-four patients developed grade 2/3 oxaliplatin-induced neuropathy. There were more patients carrying at least one GSTP1(105)Val allele among the group with grade 2/3 neuropathy (18/44, 41%) than among the group with grade 1 neuropathy (9/38, 24%), although the difference was not statistically significant (P=0.098). There were similar numbers of patients carrying at least one AGXT(105)Met allele in the grade 2/3 neuropathy (7/44, 16%) and grade 1 neuropathy groups (5/38, 13%; P=0.725). The AGXT(11)Leu allele was not found in any of our patients or controls. CONCLUSIONS: We found no significant association between oxaliplatin-induced neuropathy and the GSTP1 Ile(105)Val and AGXT Ile(340)Met polymorphisms. Given that no AGXT(11)Leu allele was found among our study population (n=177), evaluating this polymorphism in Japanese patients in future studies is likely to be uninformative. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.rights | © 2010 Elsevier | en |
dc.rights | This is not the published version. Please cite only the published version. | en |
dc.rights | この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 | ja |
dc.subject | Oxaliplatin | en |
dc.subject | Neurotoxicity | en |
dc.subject | Colorectal cancer | en |
dc.subject | GSTP1 Ile105Val | en |
dc.subject | AGXT Pro11Leu | en |
dc.subject | AGXT Ile340Met | en |
dc.title | Associations between glutathione S-transferase pi Ile105Val and glyoxylate aminotransferase Pro11Leu and Ile340Met polymorphisms and early-onset oxaliplatin-induced neuropathy. | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.ncid | AA12419531 | - |
dc.identifier.jtitle | Cancer epidemiology | en |
dc.identifier.volume | 34 | - |
dc.identifier.issue | 2 | - |
dc.identifier.spage | 189 | - |
dc.identifier.epage | 193 | - |
dc.relation.doi | 10.1016/j.canep.2010.02.008 | - |
dc.textversion | author | - |
dc.identifier.pmid | 20308030 | - |
dcterms.accessRights | open access | - |
出現コレクション: | 学術雑誌掲載論文等 |
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