メチルサイオユラシールによる実験的尿路結石に就て

Abstract

Male mice, body weight 15-20g, have been fed on standard diet containing 0.5 % methiocil (4-methyl-2-thiouracil) during above three months. After three months five mice were sacrificed, and three of them were found to have vesical calculi about the size of sesame. Some animals died after five or six months, presented vesical calculi as large as the pea. The crystalloidal component of these calculi was found to be methyl thiouracil only. It seems that these calculi were produced owing to the administration of large dose of methiocil, decrease of solubility of the urine as the result of oliguria, acidic tendency of the urine and the difficult soluble nature of methiocil. The renal pelves and ureters of the mice which produced urinary calculi presented apparent dilatation but the histological investigation of the kidney by H. E. staining, metachromasy and PAS reaction revealed no significant difference compared with the normal kidney.