前立腺癌並びに同肥大症の睾丸に就ての組織学的並びに組織化学的研究 第1報:前立腺癌並びに同肥大症の睾丸に就ての臨牀病理学的研究

Abstract

The testicles of prostatics cancer (10 cases), p rostatic hypertrophy (18 cases), and the control cases of none prostatic disease (above 40 years) were examined histologically and histochemically by the needle biopsies or autopsies. In the testicles of prostatic cancer ard hypertrophy, the decrease or disappearance of germ cells, the thickening of basement membrane of seminiferous tubules, the proliferation of connective tissue of stroma were observed. Above changes of these testicles were nonspecific one and detected commonly in aged testicles. However these changes of testicles were generally more mild than that of the control cases. According to these findings, it was presumed these testicles in prostatic cancer and hypertrophy had a relatively good function. In the cancer testicles of 5 out 10 cases treated with high dosis of estrogen administration, more marked decrease of germ cells, thickening of basement membrane of seminiferous tubules, proliferation of stroma, atrophy and decreasing tendency in number of interstitial cells of Leydig, increase of large lipid granules in the seminiferous tubules and stroma, decrease of alkaline phosphatase reaction in semis iferous tubules were observed .