Furadantin腸溶錠の尿中排泄と使用経験

Abstract

The urinary excretion of Furadantin following the oral a d ministration of enteric coated tablet 100 mg was determined by bacteriological assay and the result was conpaired with those of the uncoated tablets 100 mg, 150 mg and 200 mg. The excretion of Furadantin enteric coated tablet into the urine was apparently slower than those of the uncoated tablets but reached to sufficiently high level in one hour and kept the effective level for eight hours. Twenty-five patients with various urinary tract infections were treated with Furad a ntin enteric coated tablet 100 mg q.i.d. for seven days in average. Bacteriological and clinical cure were obtained in 3 patients, improvement in 12 patients and no improvement in 10 patients. Mild gastric discomfort and anorexia were observed in 3 of 25 patients during the treatment with Furadantin enteric coated tablet. But the reactions were apparently milder than those of the uncoated tablet and none of our patients war forced to discontinue the treatment.