尿路感染症とChymotrypsin

Abstract

It is reported that the anti-inflammatory effect of c h ymotrypsin, a proteolytic enzyme, exceeded that of trypsin and paralleled that of prednisolone, and moreover chymotrypsin caused less untoward reactions than trypsin and prednisolone. Clinical studies were made to compare the effect of chymotrypsin with that of methylprednisolone (cf. our previous report) on the chronic urinary tract infections complicated with traumatic paraplegics. Crystallized alpha chymotrypsin (Kimopsin, Eisai) alone was adm i nistered intramuscularly 25 Ch.U. once a day for 3-7 days. The effects of chymotrypsin were observed on the grade of pyuria and bacterial counts of urine, and were compared with those of methylprednisolone administered orally 12-16 mg, 3-4 times a day for 7 days. Judging from the decrease of white blood cells in urine, the anti-inflammatory effect of chymotrypsin is less remarkable than that of methylprednisolone. And it seems to be noteworthy that the decreased bacterial counts were confirmed in more than half cases after the administration of anti-inflammatory drugs, chymotrypsin and methylprednisolone. The bacteriologic cure rate was 50% after the combined administration of chymotrypsin and sensitive antibiotics, and 38% after that of methylprednisolone and sensitive antibiotics . The effect of chymotrypsin as an adjutant of antibacterial treatment exceeds that of methylprednisolone. As the side effects of chymotrypsin, the increase of bacterial counts in urine and the prolongation of bleeding time were noted. The former was of a lower grade than that of methylprednisolone and the latter was clinically insignificant. And no allergic and anaphy laxic reaction was experienced and the pains at the site of intramuscular injection were slight. Finally it may be possible to conclude that chymotrypsin is a superior anti-inflamm a tory drug to adrenocortical steroids in treating the chronic urinary tract infections .