前立腺癌の病理組織学的研究

Abstract

1. Histologic studies were made on 134 specimens of the p rostate diagnosed as carcinoma by means of routine examination. 2. New criterion for histological grading of carcinoma of the prostate, named CGS classification, was designed. CGS corresponds to "Cytological grading", "Glandular pattern''. and "Stromal condition" respectively ; and each of them was graded from 1 to 3. 134 specimens were accordingly classified. 3. In carcinoma of the p r ostate, modes of extension were found being principally related to the maintenance of glandular structure and inhibition of extension to quantity of the stroma. 4. Qualification for carcinoma, namely evidence of malignancy, was here design a ted as contiguous growth without intervening stroma. Of 134, 11 failed to fulfill this finding. Most of them were of small duct pattern with stratified epithelial cells and marked stromal fibrosis. Because of these common histologic findings this nonmalignant histologic entity was here named senile adenosis of the prostate. It was suggested that so-called occult carcinoma of the prostate might be mostly included in this condition. 5. Excellent survival rate of the pat i e nts with carcinoma of the prostate was explained histologically with emphasis on the abundant fibromuscular stroma and secondary fibrosis, as seen in estrogen therapy, by which carcinomatous extension should be potentially inhibited.