ラット前立腺の組織化学 2: 松果体,唾液腺,糖尿病,Vit-B2欠乏症及び精管結紮,肝臓障碍の影響

Abstract

Using Wistar-stain male rats, histochemical studies w ere made on influences of the pineal body, salivary glands, alloxan diabetes, Vit. B2 deficiency, ligation of the seminal ducts and liver damages upon the sexual glands and adrenal glands with a focusing of prostatic gland. 1) In one month after extirpation of the pineal body, weight and stainabilities of the adnexal, testicular and adrenal glands well sustained or increased with an evidence of hyperfunction. 2) Extirpation of the both parotid glands resulted decreases in weight and function of the adnexal glands, testicle and adrenal glands. Extirpation of the submaxillay gland resulted less influence in these organs except for slight decrease in SD activity of the prostatic gland and seminal vesicle. Administration of Parotin at the dose of 0.25 mg three times a week showed a more pronounced accerelative effects on weight and functions of the adnexal glands and testicles than that of at the dose of 0.25 mg once a week . Adrenal function was also increased. 3) In rats with alloxan diabetes, decreases in weight of the adnexal glands and activities of SD and Zn of the prostatic gland and seminal vesicle were demonstrated, of which grades progressively advanced with elapse of time. Spermatogenic function of the testicles was suppressed and weight and stainabilities of the adrenal glands were decreased. 4) In vitamen B2 deficiency, although weight and stainabilities of sexual organs were decreased, Zn stain was only turned to the better in the prostatic gland. 5) In 2 months aften ligation of the seminal ducts, decrease in prosta t i c function was only slightly demonstrated as well as decrease in weight and stainabilities of the testicle. 6) With administration of carbon-tetrachloride, weight of the testicles did not d e crease too much although decrease in weight of the prostatic gland was rather pronounced. Marked decreases in RNA, Zn and SD in the prostatic gland, decreases in SD in the seminal vesicle and 17 KS in the adrenal glands were also recognized. Administration of sexual hormones and experimentally produced thyroid dysfunctions resulted rather marked responses to the adnexal organs. Prostatic Zn content always decreased accompanied by damaged liver.