腎不全に対する滲透圧利尿剤の効果

Abstract

Recent advantage proved the osmotic diuretic function of mannitol plays as prevent effect to acute renal insufficiency due to disturbance of renal blood flow , and so the drug became to use clinically. In a total o f 15 patients , including 3 cases done nephrolithotomy who necessitated to do transient blood flow arrest , 8 cases done nephro-, uretero- cystectomy who showed decreased blood pressure during or after operation , a cases who developed shock due to incompatible blood transfusion and 3 cases of obstructive anuria associated with tuberculosis of the kidney, 20 % mannitol solution (Daiichi Pharm. Co.) mixed in various infusiug fluids was given during or after operations with sufficiently good results. In contrast to these satisfactory cases in where no much parenchymal disturbance of the kidney were recognizable, 3 cases of terminal stage of chronic nephritis who were given the drug to improve edema and to accerelate urinary output showed not only ineffectiveness on increasing urinary volume bnt also development of hyponatremia followed by unbalanced situation of electrolytes and so intensive efforts were necessary to correct the difficult situations produced by the drug. It will be important to pay much attention to renal functions whenever mannitol is administered during or after operation especially in cases of impaired renal function to avoid development of electrolytes unbalance.