Role of the urinary calcium in the growth of calcium stone

Abstract

カルシウム結石の増大率を測定し, これに影響を与える臨床的因子について検討した.男子腎結石29例中20例(蓚酸カルシウム結石5例, 蓚酸カルシウム燐酸カルシウム混合結石15例)において24時間尿中カルシウム, リン, 尿酸, マグネシウムを外来自由食下で測定した.そして結石増大率と尿中結石関連物質排泄量の関係について検討した.その結果, 結石増大率と24時間尿中カルシウム排泄量の間に有意な正の相関関係が認められた.また, 蓚酸カルシウム燐酸カルシウム混合結石の増大率は蓚酸カルシウム結石のそれより有意に高かった.以上, 尿中カルシウムはカルシウム結石の増大に重要な影響を与えるものと示唆された

We analyzed the relationship between the rate and clinical factors. The growth rate per year of the stone was measured by Nabeshima's method in 29 male patients with renal calcium stones including 7 pure calcium oxalate (CaOx) stones and 22 mixed calcium oxalate and calcium phosphate (CaOx-CaP) stones. The 24-hour urinary excretion of calcium, phosphate, uric acid and magnesium were assayed under an ambulatory free diet in 5 patients with CaOx stones and 15 with CaOx-CaP stones. The relationship between the growth rate and the urinary excretion of stone-forming parameters was examined. We found a significant positive correlation between the growth rate of calcium stones and the urinary excretion of calcium (p<0.02). In addition, the growth rate of CaOx-CaP stone was significantly higher than that of pure CaOx stone (p<0.05). In conclusion, urinary calcium is important for the growth of renal calcium stones.