Successful recovery from interstitial pneumonitis, induced by bicalutamide and leuprorelin acetate given as treatment for prostate cancer

Abstract

前立腺癌の内分泌療法においては稀な副作用として間質性肺炎がある.今回, その前立腺癌によるホルモン療法により間質性肺炎と診断され, ステロイド治療により軽快した間質性肺炎の1例(72歳男)を著者らは経験した.治療には, 迅速な診断とステロイド治療の早期開始が重要であった.しかし, 治療経過は良好であったものの, 器質化した肺が気胸を起こし, 最終的には, 患者は死亡となった

We report a case of interstitial pneumonitis induced by bicalutamide and/or leuprorelin acetate given as therapy for prostate cancer, in which the pneumonitis was successfully managed by steroid treatment. Steroids were given promptly on the day following onset of pneumonitis, and the patient (72 years old) recovered almost completely within one and a half months. Interstitial pneumonitis, induced by hormone treatment given for prostate cancer, is a reversible condition and a quick diagnosis followed by prompt, proper treatment is important to ensure a successful recovery. The patient had been free of interstitial pneumonitis for 14 months, but died of pneumothorax.