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DCフィールド | 値 | 言語 |
---|---|---|
dc.contributor.author | Yamanaka, Kazuki | en |
dc.contributor.author | Yamada, Yuji | en |
dc.contributor.author | Kobayashi, Yasuhiro | en |
dc.contributor.author | Ueno, Koichi | en |
dc.contributor.author | Takechi, Yoshizumi | en |
dc.contributor.author | Hasegawa, Emi | en |
dc.contributor.author | Chikahira, Yoshimi | en |
dc.contributor.alternative | 山中, 和樹 | ja |
dc.contributor.alternative | 山田, 裕二 | ja |
dc.contributor.alternative | 小林, 康浩 | ja |
dc.contributor.alternative | 上野, 康一 | ja |
dc.contributor.alternative | 武市, 佳純 | ja |
dc.contributor.alternative | 長谷川, 絵美 | ja |
dc.contributor.alternative | 近平, 佳美 | ja |
dc.date.accessioned | 2010-05-27T07:19:04Z | - |
dc.date.available | 2010-05-27T07:19:04Z | - |
dc.date.issued | 2003-01 | - |
dc.identifier.issn | 0018-1994 | - |
dc.identifier.uri | http://hdl.handle.net/2433/114903 | - |
dc.description.abstract | 対象は1999年7月から28ヵ月間に超音波ガイド下経直腸的前立腺生検を施行したPSA2.0~10.0ng/mlの151例で, PSA, PSA-ACT, PSAD, PSATZD, PSA-ACTD, PSA-ACTTZDを測定し, ROC解析を用いてこれらのパラメーターを検討した.系統的6ヶ所生検にて151例中36例から前立腺癌が検出された.ROC解析ではPSA-ACTTZDのAUCが最大となり, PSA-ACTTZDは有意差をもってPSA単独より有用な指標と考えられた.PSA-ACTTZDのカットオフ値を0.20ng/ml2を設定することにより, 感度90%, 特異度55%で不必要な生検を回避できる可能性が示唆された | ja |
dc.description.abstract | We examined the usefulness of prostate specific antigen alph-1-antichymotrypsin complex (PSA-ACT) and its indices for the detection of prostate cancer in patients with a prostate specific antigen (PSA) level between 2.1 and 10.0 ng/ml. Between July 1999 and October 2001, 151 patients with a PSA level between 2.1 and 10.0 ng/ml underwent a systematic biopsy under transrectal ultrasound (TRUS) guidance. The clinical values of total PSA, PSA-ACT, PSA density (PSAD), PSA-ACT density (PSA-ACTD), PSA transition zone density (PSATZD) and PSA-ACT transition zone density (PSA-ACTTZD) for the detection of prostate cancer were compared by using receiver operating characteristic (ROC) curve analysis. Of the 151 patients, 36 (23.8%) were histologically confirmed as having prostate cancer. The differences between patients with prostate cancer and benign prostatic disease were significant with respect to the PSA and PSA-ACT related parameters examined in this study. According to ROC curve analysis, the area under the curve (AUC) of PSA-ACTTZD was the greatest of all the parameters. The differences was significant between the AUC of PSA-ACTTZD and total PSA (p < 0.05). The cutoff value of PSA-ACTTZD with 0.20 ng/ml2 showed the highest sum of sensivitity (90%) and specificity (55%). Also, in 86 patients with a PSA level between 2.1 and 6.0 ng/ml, the AUC of PSA-ACTTZD was the greatest of all the parameters. Measuring the level of PSA-ACT and its indices may provide a better differentiation of prostate cancer and benign prostatic disease than total PSA alone in patients with intermediate PSA levels. PSA-ACTTZD is the most useful indicator among PSA-ACT and its volume indices. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | 泌尿器科紀要刊行会 | ja |
dc.subject | Prostate cancer | en |
dc.subject | Prostate specific antigen alpha-l-antichymotrypsin | en |
dc.subject | Transtion zone | en |
dc.subject.ndc | 494.9 | - |
dc.title | The significance of prostate-specific antigen alpha-1-antichymotrypsin complex and its indices for the detection of prostate cancer | en |
dc.title.alternative | 前立腺癌診断におけるPSA-ACTおよびPSA-ACT volume indexの有用性についての検討 | ja |
dc.type | departmental bulletin paper | - |
dc.type.niitype | Departmental Bulletin Paper | - |
dc.identifier.ncid | AN00208315 | - |
dc.identifier.jtitle | 泌尿器科紀要 | ja |
dc.identifier.volume | 49 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | 5 | - |
dc.identifier.epage | 10 | - |
dc.textversion | publisher | - |
dc.sortkey | 02 | - |
dc.address | Department of Urology, Hyogo Prefectural Awaji Hospital | en |
dc.address | Department of Laboratory Medicine, Hyogo Prefectural Awaji Hospital. | en |
dc.address.alternative | 兵庫県立淡路病院 泌尿器科 | ja |
dc.address.alternative | 兵庫県立淡路病院検査部 | ja |
dc.identifier.pmid | 12629773 | - |
dcterms.accessRights | open access | - |
dc.identifier.pissn | 0018-1994 | - |
dc.identifier.jtitle-alternative | Acta urologica Japonica | la |
dc.identifier.jtitle-alternative | Hinyokika Kiyo | en |
出現コレクション: | Vol.49 No.1 |
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