VAC(Vincristine, Actinomycin-D, Cyclophosphamide)療法にて完全寛解をえた再発性小児精巣卵黄嚢腫の1例

Abstract

高位精巣摘除術2年後に後腹膜に再発した3歳男児の精巣卵黄嚢腫例に対し化学療法およびリンパ節廓清術を施行し, 完全寛解をえた。VAC療法により顆粒球減少症・脱毛・口内炎等の合併症を認めたが, 顆粒球減少症に対してはG-CSFの投与により予定した治療を完遂しえた。小児精巣腫瘍に対するVAC療法は有効で安全な治療法と考えられた

A case of recurrent yolk sac tumor in a three-year-and five-month old child is reported. Left high orchiectomy was performed two years earlier at which time no evidence of metastatic disease was demonstrated. Twenty-four months postoperatively, serum alpha-fetoprotein (alpha-FP) was elevated and recurrent mass appeared in the left para aortic region. Treatment by VAC regimen consisting of vincristine, actinomycin D and cyclophosphamide was performed. Complete response was obtained after two courses of this therapy, which was confirmed by retroperitoneal lymphadenectomy. We believe that this chemotherapy is effective and safe for the treatment of yolk sac tumor of infantile testis.