ダウンロード数: 198
このアイテムのファイル:
ファイル | 記述 | サイズ | フォーマット | |
---|---|---|---|---|
43_835.pdf | 303.03 kB | Adobe PDF | 見る/開く |
完全メタデータレコード
DCフィールド | 値 | 言語 |
---|---|---|
dc.contributor.author | 川喜田, 睦司 | ja |
dc.contributor.author | 吉田, 修 | ja |
dc.contributor.author | RATLIFF, Timothy L. | en |
dc.contributor.alternative | KAWAKITA, Mutsushi | en |
dc.contributor.alternative | YOSHIDA, Osamu | en |
dc.contributor.alternative | RATLIFF, Timothy L. | en |
dc.date.accessioned | 2010-05-28T06:15:04Z | - |
dc.date.available | 2010-05-28T06:15:04Z | - |
dc.date.issued | 1997-11 | - |
dc.identifier.issn | 0018-1994 | - |
dc.identifier.uri | http://hdl.handle.net/2433/116059 | - |
dc.description.abstract | Prostate cancer;Progression model;Gene therapy;Osteocalcin promoter;PSA promoter | en |
dc.description.abstract | A promising approach to cancer immunotherapy is immunization with modified tumor cells carrying cytokine or immunomodulatory genes. Cytokine genes (tumor necrosis factor-alpha, interleukin 2, interferon gamma) and costimulatory molecule, B7-1, were incorporated into canarypox virus, ALVAC, which does not replicate in infected mammalian cells, and highly attenuated vaccinia virus, NYVAC. We examined the effect of local cytokine production on the growth of the mouse prostate tumor, RM-1, and the mouse bladder tumor, MBT-2. The vectors expressed the high levels of cytokines and B7-1 and the tumor growth of infected cells was significantly inhibited. The mice immunized with irradiated MBT-2 cells infected with ALVAC-interleukin 2 were protected against the subsequent challenge of parental tumor cells. We conclude that poxvirus vectors are useful for gene delivery in immunotherapy studies because of their infection efficiency, their capability of high gene product expression, their safety, and their case of handling. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | jpn | - |
dc.publisher | 泌尿器科紀要刊行会 | ja |
dc.subject | Gene therapy | en |
dc.subject | Poxvirus | en |
dc.subject | Canarypox virus | en |
dc.subject | Cytokines | en |
dc.subject | Immunotherapy | en |
dc.subject.ndc | 494.9 | - |
dc.title | Poxvirusによる遺伝子導入 | ja |
dc.title.alternative | Poxvirus vectors for gene transfer | en |
dc.type | departmental bulletin paper | - |
dc.type.niitype | Departmental Bulletin Paper | - |
dc.identifier.ncid | AN00208315 | - |
dc.identifier.jtitle | 泌尿器科紀要 | ja |
dc.identifier.volume | 43 | - |
dc.identifier.issue | 11 | - |
dc.identifier.spage | 835 | - |
dc.identifier.epage | 838 | - |
dc.textversion | publisher | - |
dc.sortkey | 15 | - |
dc.address | 京都大学医学部泌尿器科学教室 | ja |
dc.address | 京都大学医学部泌尿器科学教室 | ja |
dc.address | ワシントン大学医学部泌尿器外科 | ja |
dc.address.alternative | the Department of Urology, Faculty of Medicine, Kyoto University | en |
dc.address.alternative | the Department of Urology, Faculty of Medicine, Kyoto University | en |
dc.address.alternative | the Division of Urologic Surgery, Washington University School of Medicine | en |
dc.identifier.pmid | 9436032 | - |
dcterms.accessRights | open access | - |
dc.identifier.pissn | 0018-1994 | - |
dc.identifier.jtitle-alternative | Acta urologica Japonica | la |
dc.identifier.jtitle-alternative | Hinyokika Kiyo | en |
出現コレクション: | Vol.43 No.11 |
このリポジトリに保管されているアイテムはすべて著作権により保護されています。