腎細胞癌のマーカーとしてのImmunosuppressive Acidic Protein (IAP)の有用性について

Abstract

Immunosuppressive acidic protein (IAP) exhibits various types of immunosuppressive activity and is said to increase in cancer hosts. Based on measurements of IAP levels in normal subjects, cases of renal cysts and 46 cases of renal cell carcinoma we reached the following conclusions: The IAP levels in normal subjects ranged from 250-530 micrograms/ml, with a mean +/- S.D. of 362.5 +/- 68.9 micrograms/ml, which was comparable to the values in renal cyst cases (250-470 micrograms/ml, mean +/- S.D.: 353 +/- 70 micrograms/ml). 475 micrograms/ml was taken as the upper limit of the normal range. The pretreatment IAP values for cases of renal cell carcinoma ranged from 330-1, 780 micrograms/ml, with a mean +/- S.D. of 820 +/- 820 and 73% were considered positive (i.e. beyond the 475 micrograms/ml limit). There was a statistical significance of p less than 0.01 between normal subjects and renal cell carcinoma cases and also between renal cyst cases and renal cell carcinoma cases. When the cases of renal cell carcinoma were divided into those with a pretreatment IAP level of 475 micrograms/ml or less and those with more than 475 micrograms/ml, the 3-year survival of the former was 90%, whereas that of the latter group was 39%, showing a statistically significant difference with p less than 0.05. Comparison of the IAP levels in the group of total nephrectomy cases that did not develop recurrence and those in which recurrence was recognized, revealed significantly higher IAP levels in the latter (p less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)