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タイトル: | Anti-androgenの性機能におよぼす影響 - アリルエストレノールおよび酢酸クロルマジノンの二重盲検法比較試験 第2報:自記式質問紙法による検討 - |
その他のタイトル: | Effects of anti-androgens on sexual function. Double-blind comparative studies on allylestrenol and chlormadinone acetate. Part II: Self-assessment questionnaire method |
著者: | 熊本, 悦明 ![]() 山口, 康宏 ![]() 佐藤, 嘉一 ![]() 丹田, 均 ![]() 加藤, 修爾 ![]() 毛利, 和富 ![]() 門野, 雅夫 ![]() 本間, 昭雄 ![]() 三宅, 正文 ![]() 青木, 正治 ![]() 恒川, 琢司 ![]() 江夏, 朝松 ![]() 丸田, 浩 ![]() 大堀, 勉 ![]() 青木, 光 ![]() 萬谷, 嘉明 ![]() 鈴木, 騏一 ![]() 石井, 延久 ![]() 入沢, 千晶 ![]() 今村, 一男 ![]() 吉田, 英機 ![]() 白井, 将文 ![]() 高波, 真佐治 ![]() 松島, 正浩 ![]() 田島, 政晴 ![]() 鈴木, 良二 ![]() 松本, 英亜 ![]() 牧, 昭夫 ![]() 藤尾, 幸司 ![]() 中山, 孝一 ![]() 深澤, 潔 ![]() 三浦, 一陽 ![]() 長田, 尚夫 ![]() 矢島, 通孝 ![]() 片山, 喬 ![]() 寺田, 為義 ![]() 守殿, 貞夫 ![]() 安野, 博彦 ![]() 井谷, 淳 ![]() 斉藤, 宗吾 ![]() 今川, 章夫 ![]() 前林, 浩次 ![]() 荒木, 徹 ![]() 高本, 均 ![]() 杉山, 善朗 ![]() 中村, 浩 ![]() 志田, 圭三 ![]() |
著者名の別形: | Kumamoto, Yoshiaki Yamaguchi, Yasuhiro Sato, Yoshikazu Tanda, Hitoshi Kato, Shuji Mori, Kazutomi Kadono, Masao Honma, Akio Miyake, Masafumi Aoki, Masaharu Tsunekawa, Takuji Enatsu, Chosyo Miaruta, Hiroshi Ohhori, Tsutomu Aoki, Hikaru Banya, Yoshiaki Suzuki, Kiichi Ishii, Nobuhisa Irisawa, Chiaki Imamura, Kazuo Yoshida, Hideki Shirai, Masafumi Takanami, Masaharu Matsushima, Masahiro Tajima, Masaharu Suzuki, Ryoji Matsumoto, Hidetsugu Maki, Akio Fujio, Kouji Nakayama, Koichi Fukazawa, Kiyoshi Miura, Kazukiyo Osada, Takao Yajima, Michitaka Katayama, Takashi Terada, Tameyoshi Kamidono, Sadao Yasuno, Hirohiko Itani, Atsushi Saito, Sogo Imagawa, Akio Maebayashi, Koji Araki, Tohru Takamoto, Hitoshi Sugiyama, Yoshio Nakamura, Kou Shida, Keizo |
キーワード: | Antiandrogen Sexual function Questionnaire Allylestrenol. Benign prostatic hypertrophy |
発行日: | Feb-1990 |
出版者: | 泌尿器科紀要刊行会 |
誌名: | 泌尿器科紀要 |
巻: | 36 |
号: | 2 |
開始ページ: | 227 |
終了ページ: | 244 |
抄録: | Allylestrenol (ALE) and chlormadinone acetate (CMA) were administered to patients with prostatomegaly by the double-blind method, and a self-assessment questionnaire method developed by the authors was used to study the influence of these two antiandrogens on their sexual function. Each test drug was orally administered to 58 patients, in a daily dosage of 50 mg for 12 consecutive weeks. The questionnaires consisted of 6 categories each consisting of 5 questions, or 30 questions in total. The 6 categories were "sexual desire, " "erectile capacity" and "ejaculation, " which relate to the sexual function, and "living environment (including the frequency of sex), " "dysuria" and "dummy (personality)." Each question was graded into 0-10 points, and each patient was requested to circle the number which best described his status. The scores were compiled and statistically analyzed. Many patients were senile. Evaluable answers were obtained for 99 (85.3%) of the 116 patients. Factor analysis based on the preadministration scores confirmed the contents of the questionnaires to be appropriate for the objectives of the present study. Multiple regression analysis revealed a high correlation between the self-assessment scores and objective data (nocturnal penile tumescence values; NPT values) when dropout cases due to a decrease in the sexual function and non-replying cases were excluded. The self-assessment questionnaire method was concluded to be as useful an objective test method as the NPT measurement for examining the sexual function. Aggravation of the "frequency of urination during night" was conspicuous in the CMA group, and there was a significant difference (p less than 0.05) in this parameter between the two groups. Except for this parameter, dysuria was improved in both administration groups, and there was no significant difference in the efficacy of the two drugs. Both drugs tended to suppress overall sexual function, but the suppression was less severe in the ALE group. Especially the suppression was significantly (p less than 0.05) lower in the ALE group regarding the 3 parameters of "contact sexual arousal, " "contact erection" and "morning erection", which are included in the category of "sexual desire" or "erectile capacity." Also, suppression of "frequency of sex" and "intensity of sexual desire" tended to be lower in the ALE group at a level of significance of p less than 0.1. Regarding questions in the category of "ejaculation, " the incidence of non-replies was high in both groups, but its rate was higher in the CMA group. |
URI: | http://hdl.handle.net/2433/116822 |
PubMed ID: | 1693038 |
出現コレクション: | Vol.36 No.2 |
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