HLBIによる尖圭コンジロームの治療経験

Abstract

αインターフェロンを用いて尖圭コンジローム18例の治療を試みた.1)局所投与を行った17例中完全消失は, 6例に認めた.2)総投与量が12×106単位を越えた, 11例での完全消失は5例であった.3)完全消失例の6ヵ月以内の再発は認められなかった

Eighteen cases of condyloma acuminata were treated by human lymphoblastoid interferon (HLBI). Seventeen were male and one was female. Five cases were recurrent cases. Except one patient, all the patients were administered HLBI by intralesional injection. Five patients were treated by single injection. Others were given 2 to 8 injections during one to 5 weeks. Total dose varied from 3 x 10(6) to 24 x 10(6) U. Of the eighteen patients, 6 showed a complete response and 3 a partial response (greater than 50% reduction in size of the lesion). In 5 of the 11 patients (45%) who were treated with a total dosage of more than 12 x 10(6) U, the lesion was completely cleared. Six patients who showed a complete response did not experience recurrent disease during the 6-month follow-up period. In conclusion, intralesional administration of HLBI for condyloma acuminata proved to be effective.