膀胱癌の臨床的検討

Abstract

1985年1月～1989年12月の間の原発性膀胱癌185例は29～95歳で, 男女比は3.1:1であった.初回治療後の累積3及び5年生存率はそれぞれ73.3及び71.5%であった.組織学的に, 17例は移行細胞癌G1 (grade 1), 69例はG2 (grade 2), 69例はG3 (grade 3)であった.stage pTisが5例, pTaが6例, pT1が41例, pT2が15例, pT3aが9例, pT3bが14例, pT4が6例であった.腫瘍のstage, grade, 大きさ, 及び型が予後を良く反映した.G2とG3, 及びstage T1とT2との間では生存率に有意差が認められた.low-grade low-stage腫瘍は患者の44%で再発した.病理学的stageはgradeと良く関係していた.特にG1膀胱腫瘍では筋層侵襲は認められなかった

A clinical survey was performed on 185 cases of primary bladder cancer treated at our Department of Urology, between January, 1985 and December, 1989. Clinicopathological profiles of patients and survival rates according to these profiles were investigated. The patients were between 29 and 95 years old. The male to female ratio was 3.1 to 1. The cumulative survival rate after the first treatment was 73.3% and 71.5% at 3 and 5 years, respectively. Histologically, 17 cases were diagnosed as transitional cell carcinoma G1, 69 cases as G2 and 69 cases as G3. 5 cases were diagnosed as stage pTis, 6 cases as pTa, 41 cases as pT1, 15 cases as pT2, 9 cases as pT3a, 14 cases as pT3b and 6 cases as pT4. Stage, grade, size and type of tumors reflected the prognosis well. Significant differences were observed between the survival rates of the patients with grade G2 and grade G3, and the patients with stage T1 and stage T2. Although low-grade low-stage tumors recurred in 44% of the patients. The pathological stage showed a good relation to the grade. In particular, none of the G1 bladder tumors had muscle invasion in our series.