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タイトル: | 一過性心電図変化を伴ったTranilast (Rizaben)による薬剤性膀胱炎の1例 |
その他のタイトル: | A case of tranilast-induced cystitis with transient ECG changes |
著者: | 藤井, 靖久 遠坂, 顕 安島, 純一 岡, 薫 小出, 直 |
著者名の別形: | Fujii, Yasuhisa Tosaka, Akira Ajima, Junichi Oka, Kaoru Koide, Tadashi |
キーワード: | Drug-induced cystitis Eosinophilic cystitis Tranilast Hypereosinophilic heart syndrome |
発行日: | Aug-1992 |
出版者: | 泌尿器科紀要刊行会 |
誌名: | 泌尿器科紀要 |
巻: | 38 |
号: | 8 |
開始ページ: | 953 |
終了ページ: | 956 |
抄録: | A case of tranilast (Rizaben)-induced cystitis accompanied with possibly hypereosinophilic heart syndrome was described. A 75-year-old male, who had been taking tranilast for allergic dermatitis for two months, was admitted for severe bladder stimulating symptoms which was unresponsive to antibiotic therapies. Clinical examination revealed tenderness of the prostate, aseptic pyuria, eosinophilia, liver dysfunction and electrocardiographic disorders including atrial fibrillation, T-wave inversions and lowered ST segment without any cardiac symptoms. Cystitis symptoms, pyuria, eosinophilia and liver dysfunction improved within several days after discontinuance of tranilast, and ST-T changes on ECG gradually normalized within a few months. Tranilast-induced cystitis has been demonstrated as a type of eosinophilic cystitis. Since pathologic findings of eosinophilic cystitis and hypereosinophilic heart syndrome are markedly similar and all symptoms and signs disappeared after deprivation of tranilast, it appears likely that eosinophilic inflammation was induced to the heart, liver, bladder and prostate of the current patient by tranilast. |
URI: | http://hdl.handle.net/2433/117620 |
PubMed ID: | 1384294 |
出現コレクション: | Vol.38 No.8 |
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