Paratesticular leiomyosarcoma with elevated serum basic fetoprotein: a case report

Abstract

血清basicfetoproteinが高値を呈した傍精巣平滑筋腫の1例を報告する.患者は45歳男性で6ヵ月前より左陰嚢内容の無痛性腫大を自覚し当科を受診した.左精巣腫瘍の診断の下に左高位除聖術が施行された.肉眼的および病理組織学的所見より摘除腫瘍は傍精巣平滑筋肉腫であった.血清basicfetoproteinは新しく同定された胎児性蛋白で, ある種の悪性腫瘍で高値を示す.自験例では術前血清basicfetoprotelnが高値を示し, その値は患者の病状とよく相関した.化学療法および, 肺転移巣切除にもかかわらず患者の全身状態が悪化するとともに血清baslcfetoprotein値は上昇し, 患者は入院後2年6ヵ月目に癌死した.血清basicfetoproteinは自験例では有用な腫瘍マーカーであると思われた.

A case of paratesticular leiomyosarcoma associated with elevated serum basic fetoprotein level is reported. A 45-year-old male visited our hospital with a 6-month history of a painless left scrotal mass. High orchiectomy was performed under the diagnosis of left testicular tumor. Macroscopic and microscopic examination of the resected tumor demonstrated it to be paratesticular leiomyosarcoma. The value of serum basic fetoprotein, which is a newly identified oncofetal protein and useful as a tumor marker in some kinds of malignant neoplasm, was elevated before therapy, and its fluctuation was correlated with his clinical course. In spite of chemotherapy and resection of metastatic lesions in the lung, his condition gradually deteriorate with increasing serum basic fetoprotein level, and he died with carcinomatosis 2 years and 6 months after his admission. We suggest that basic fetoprotein is a useful tumor marker in this disease.