男性不妊症に対する漢方療法効果: 1)人参湯と八味地黄丸併用効果

Abstract

男性不妊症患者中, とくに, 主として精子数が低下している症例に対し人参湯, 八味地黄丸各7.5 grを12週以上投与し, その臨床的効果に関し検討した.1)精液量, 精子運動率増加はほとんどみとめられなかった.2)精子数は53.5%の増加を認め, 精子数増加に約90日を要したのは精子形成, 成熟, 分泌に要する日数とよく一致していた.3) FI 180以上の症例は10例中3例(30.0%)であった.4) 10例中2例(20.0%)に妊娠の成立を認めた.5)副作用として, 10例中3例に心窩部痛をみとめたが投薬中止までにはいたらなかった.6)臨床検査値上, 人参湯と八味地黄丸併用でのデーターの変化はみとめられなかった

Ten patients (age range, 28 to 36 years with a mean of 32.3 years) with male infertility were orally given Ninjinto and Hachimijiogan concomitantly at a daily dose of 7.5 g each for 96 to 182 days (mean 116.8 days). Ten percent of these patients showed remarkable improvement in their volume of semen, 10% showed improvement and 80.0% showed no improvement. Thirty percent of these patients showed remarkable improvement in the number of sperm, 10.0% showed improvement, and 60.0% showed no improvement. Twenty percent of these patients showed remarkable improvement in their sperm mobility, 30.0% showed improvement and 50.0% showed no improvement. The fertility index was improved markedly in 60.0%, improved in 20.0% and not improved in 20.0%. The spouses of 2 patients became pregnant. Side effects were seen in only 30.0% (epigastralgia) of these patients. Laboratory examination of these patients revealed no significant change. These results suggested that concomitant administration of Ninjinto and Hachimijiogan is effective on patients with male infertility.