Ureaplasma urealyticumと精子に関する研究 化学療法前・後における精子形態の比較―

Abstract

Ureaplasmaの感染が精子形態に及ぼす影響を調べるため, Ureaplasma陽性例に化学療法を行い, 各例ごとにUreaplasma陽性時と陰性時の精子頭部と尾部の形態を検討した.1)正常対照fertile maleの精子形態はoval formが約70%, tapering formは12.7%, 尾部のcoiled tailとfuggy granular tailの検出率はそれぞれ14.7, 9.4%であった.2)化学療法後Ureaplasmaが陰性化した21例の治療前後の精子頭部tapering form, 他の頭部形態に有意差なく, 尾部coiled tail, fuzzy granular tailともにUreaplasma陽性時の方が有意に高率であった.3)化学療法無効5例の頭部tapering formの検出率はfertile maleより, 高率であったが, 治療前後に有意差はなかった.他の頭部形態の検出率にも治療前後で有意差はなかった.尾部のcoiled tailとfuzzy granular tailの検出率はfertile maleよりも高かったが, 治療前後に有意差はなかった.4)化学療法有効例のU. I.(Ureaplasma Index)=(coiled tailの検出率%)×(fuzzy granular tailの検出率%)はUreaplasma陽性時の方が高かったが, 無効例では治療前後で有意差はなかった

Spermiogram (morphology of sperm heads and tails) was evaluated in 21 men visiting our infertility clinic before and after the eradication of genital infection with Ureaplasma urealyticum. The percentage of coiled tails and fuzzy granular tails were decreased after eradication of Ureaplasma but there were no significant changes in the morphologic characteristics of sperm heads. Spermiogram was also analysed in 5 men who were unsuccessfully treated for genital Ureaplasma infection. In this group there were no significant changes in the morphologic characteristics of sperm heads and tails before and after chemotherapy.