前立腺肥大症の保存的療法 --八味地黄丸の増量による臨床効果の検討および「証」と臨床効果の関係について--

Abstract

前立腺肥大症にツムラ八味地黄丸を7.5 g/日に増量し, その効果を5 g/日投与した成績と比較した.より高い有効率をえた.八味地黄丸の「証」を点数化し, これと有効性との関係を検討した.「証」の点数化にも問題はあるが, 今回の検討から本剤の臨床効果の発現は「証」とあまり関係がないとの印象を得た.長期間の投与にかかわらず, みるべき副作用がなく, この薬剤の前立腺肥大症の保存的治療の有用性に対し, かなり良い評価ができると思われた

Tsumura Hachimijiogan, 7.5 g a day, was administered to 30 patients with benign prostatic hypertrophy (BPH). Clinical effects were estimated based on subjective symptoms and objective findings obtained by uroflowmetry. Twenty patients (66.7%) showed improvement of subjective symptoms and 14 patients (46.7%) showed good response in uroflowmetry. An improvement of overall clinical efficacy was observed in 21 patients (70%). These results were better than those obtained with 5.0 g a day doses of Tsumura Hachimijiogan. No significant relation between the "Sho" in Chinese medicine and the clinical effects of Hachimijiogan was detected. No side effects or abnormal laboratory data were found in any of these 30 patients.